Avantor Named Best Bioprocessing Supplier in Cell and Gene Therapy at the Biopharma Excellence Awards India Edition

Award recognizes Avantor’s outstanding efforts to expand the market reach for life-altering innovative cell and gene therapies

Pune, INDIA, April 3, 2023 – (ACN Newswire) – Avantor, Inc., a leading global provider of mission-critical products and services to customers in the life sciences, education and government, advanced technologies and applied materials industries, has been honored with the Best Bioprocessing Supplier Award for Cell and Gene Therapy at the Biopharma Excellence Awards (BEA) India Edition 2023, organized by IMAPAC in Pune, India.

Ganesh Bade – Head of Biopharma India Middle East & Africa (IMEA), Avantor (right) receiving the accolade at the Awards ceremony.

The award recognizes Avantor’s outstanding efforts to support the expansion of life-altering innovative cell and gene therapies to treat complex disease. Avantor is focused on making valuable contributions to cell and gene therapy production and offers expertise, technology capabilities and commitment to providing solutions. Recently, Avantor was also accorded the Best Bioprocessing Company in Chromatography at the Asia-Pacific Bioprocessing Excellence Awards (ABEA) 2023 held in Singapore.

Ganesh Bade, Head Biopharma India Middle East and Africa (IMEA) at Avantor, said, “Cell and gene therapy is considered a game-changer for the biopharma industry. But the real effort lies in supplying this life altering solution at a reasonable cost to those in need. With high purity production chemicals, sterile fluid transfer systems, cell culture components and excipient technologies, Avantor is advancing the scalability and manufacturability of viral vector production to cell and gene therapies.”

“One of the most revolutionary modalities rising in the biopharmaceutical sector is cell and gene therapies. Avantor offers a comprehensive range of bioprocessing solutions such as media and supplements, single-use technologies, and custom development services to help accelerate the development and commercialization of cell and gene therapies,” said Amit Sehgal, Managing Director, Avantor India. “With this award, we are renewing our commitment to make cell and gene therapy successful and supply it with greater efficacy and reduced risk.”

Avantor provides compliant materials in scalable formats and single-use solutions for viral vector, CAR-T and gene therapies manufacturing, that have the potential to help reduce contamination risk, improve resource efficiency and reduce labor and energy costs. As part of its regulatory support services, Avantor also helps customers navigate the complex regulatory landscape of cell and gene therapy development and commercialization.

The Best Bioprocessing Supplier in Chromatography award recognizes Avantor’s ongoing efforts to provide innovative chromatography solutions that enable biopharmaceutical manufacturers to optimize processes and enhance product quality. With over four decades of experience in bioprocessing, Avantor is committed to addressing the complex challenges of downstream chromatography by providing a comprehensive range of equipment, products and services.

About Avantor

Avantor®, a Fortune 500 company, is a leading global provider of mission-critical products and services to customers in the biopharma, healthcare, education & government, and advanced technologies & applied materials industries. Our portfolio is used in virtually every stage of the most important research, development and production activities in the industries we serve. Our global footprint enables us to serve more than 300,000 customer locations and gives us extensive access to research laboratories and scientists in more than 180 countries. We set science in motion to create a better world. For more information, visit avantorsciences.com and find us on LinkedIn, Twitter and Facebook.

About Bioprocessing Excellence Awards (ABEA) India Edition 2023

The Biopharma Excellence Awards (BEA) India 2023 seeks to recognize exceptional biologics and vaccine experts, organizations and technologies that facilitate vaccine R&D and biologics manufacturing excellence at enhanced speed, reduced cost and superior quality. The BEA India Edition 2023 applauds extraordinary leaders & trendsetters of today and inspires the innovators of tomorrow.

Regional Media Contact:
Christina Koh
Director, Communications – AMEA
Avantor
M: +65 9720 0169
Christina.Koh@avantorsciences.com



Copyright 2023 ACN Newswire. All rights reserved. http://www.acnnewswire.com

Sino Biopharm (1177.HK) Announces 2022 Annual Results

HONG KONG, Mar 31, 2023 – (ACN Newswire) – Sino Biopharmaceutical Limited ("Sino Biopharm" or the "Company", together with its subsidiaries, the "Group") (HKEX:1177), a leading innovation-driven pharmaceutical conglomerate in the PRC, has announced its audited financial results for the year ended 31 December 2022.




Development Highlights

Oncology Innovative Drugs
— Focus V (Anlotinib Hydrochloride Capsules) has been approved for five indications: third-line non-small cell lung cancer, third-line small cell lung cancer, soft tissue sarcoma, medullary thyroid cancer and differentiated thyroid cancer.
— The Phase III clinical trials of Anlotinib in combination with TQB2450 (PD-L1) for the treatment of first-line small cell lung cancer has completed interim analysis and met the pre-specified endpoint.
— In addition, 12 new indications for Anlotinib have also entered Phase III clinical trials, including the combination of Anlotinib with Penpulimab monoclonal antibody, Anlotinib with TQB2450 (PD-L1), Anlotinib with chemotherapy, and other treatment options, for which marketing applications are expected to be submitted progressively in the next one to two years.
— Annike (Penpulimab monoclonal antibody injection) injection was approved in January 2023 for the treatment of first-line locally advanced or metastatic squamous non-small cell lung cancer with chemotherapy. To date, the product has been approved for two indications: third-line classic Hodgkin's lymphoma and first-line squamous non-small cell lung cancer. In addition, it has one indication (third-line nasopharyngeal carcinoma) under marketing review.
— F-627 (Efbemalenograstim alpha, long-acting granulocyte colony-stimulating factor) is currently in the marketing application stage. F-627 is currently the only G-CSF drug on the market that has conducted simultaneous research head-to-head with both short-acting and long-acting G-CSF in large sample sizes. Phase III clinical trials have been completed with marketing applications submitted in China and the United States. The Group expects that the marketing application will be approved in China in 2023. With its strong oncology sales team, Sino Biopharm is confident in a smooth launch and rapid market penetration of the product.

Liver Disease Innovative Drugs
— Lanifibranor (pan-PPAR agonist) is an orally-available small molecule. The product is currently undergoing Phase III clinical trials globally, and is the first oral drug for NASH that has entered Phase III clinical trials in China, to address a large clinical unmet need in the China NASH market.

Respiratory System Innovative Drugs
— Ensitrelvir (3CL protease inhibitor) is a novel oral drug for the treatment of COVID-19. The drug has the potential to become a good oral drug for the treatment of COVID-19.

Surgery/Analgesia Innovative Drugs
— PL-5, an antimicrobial peptide product that is the first newly designed non-antibiotic antimicrobial drug with a broad antibacterial spectrum. The product has completed a Phase III clinical study in China for the treatment of secondary wound infections, and the Group expects to file a marketing application within this year. When the product is launched, it will be the first antimic robial peptide product available in China.

Generic Drugs
— As of the end of the reporting period, the Group's generic drug products, with annual revenue of more than RMB500 million (excluding exclusive products), have been included in the scope of centralized drug procurement. The stock of generic drugs that has not been included in the scope of centralized drug procurement has been cleared, hence, eliminating its risk exposure in centralized drug procurement.

During the year, the Group recorded revenue of approximately RMB28.78 billion, an increase of approximately 7.1% over last year. Profit attributable to the owners of the parent company was approximately RMB2.54 billion. Earnings per share attributable to the owners of the parent company were approximately RMB13.66 cents, a decrease of approximately 82.4% over last year. Excluding the share of profits and losses of associates and a joint venture (net of related tax and non-controlling interests), one-off adjustments for the impairment and fair value changes of certain assets and liabilities (net of related tax and non-controlling interests), fair value losses of current equity investments, share-based payments, loss on extinguishment of partial convertible bond, fair value gain of convertible bond embedded derivative component, effective interest expenses, exchange gain and fair value losses of derivative financial instruments in relation to foreign currency forward contracts of the convertible bond debt component, adjusted non-HKFRS profit attributable to the owners of the parent was approximately RMB2.99 billion, an increase of around 16.4% over last year. The Group's liquidity remains strong, with total fund reserve at approximately RMB22.96 billion, including cash and bank balances classified under current assets of approximately RMB12.07 billion, bank deposit classified under non-current assets of approximately RMB6.35 billion, and the wealth management products of approximately RMB4.54 billion in aggregate.

The Board of Directors has recommended a final dividend payment of HK6 cents per share. Together with the interim dividend of HK6 cents already paid, the total dividend for the year amounted to HK12 cents (2021: HK8 cents).

Sales: Sales revenue contributed by new products and innovative drug products rises relied on a strong sales system
The Group continues to focus on developing innovative medicines in four therapeutic areas and has benefited significantly from the continuous and huge investment it has made in R&D over the years. During the year, sales revenue from new products (products launched within five years) launched amounted to RMB12.51 billion, a 19.8% year-on-year increase, accounting for 43.5% of the Group's total revenue for the year, up from 38.9% for last year. Revenue from innovative drugs amounted to RMB6.75 billion, up by 20.0% year-on-year, and accounted for 23.5% of the Group's total revenue.

During the year, the Group's sales contribution continued to be led by drugs in the areas of oncology, surgery/analgesia, liver disease and respiratory system. Among them, the sales of oncology medicines amounted to approximately RMB9.19 billion, up by approximately 14.3% for last year, representing approximately 31.9% of the Group's revenue. The sales of surgery/analgesia and liver disease amounted to approximately RMB4.88 billion and RMB3.84 billion, respectively, representing approximately 17% and 13.3% of the Group's revenue, respectively. In addition, sales contributions from various areas such as respiratory, cardio-cerebral vascular medicines and others were comparable. Among them, the sales of respiratory and cardio-cerebral vascular medicines accounted for approximately 10.2% and 9.4% of the Group's revenue, respectively.

R&D: Continued to focus on R&D of innovative medicines, emphasizes protection of intellectual property rights
The Group has continued to focus its R&D efforts on new medicines in four therapeutic areas, namely
oncology, liver disease, respiratory system and the surgery/analgesia. As of the end of the reporting period, the Group has 103 products under development, including 53 oncology products, 12 liver disease products, 26 respiratory system products, and 12 surgery/analgesia products, involving a total of 58 Category I innovative products.

The Group also emphasizes the protection of intellectual property rights. It encourages its member enterprises to apply for patent applications as a means to enhance the Group's core competitiveness. During the year, the Group filed 1,006 new patent applications and received 280 authorized patent notices.

Prospects: Focus on main four therapeutic areas while the innovation and transformation have entered the harvest stage
As the pharmaceutical industry is likely to pick up rapidly. The Group has closely followed the development of the country, society and industry, and adjusted its development strategy in a timely manner. It has actively conducted organizational integration, optimized the internal organizational structure of the Group, and accelerated construction of business teams across different channels, in order to grow its business rapidly and deliver results in a stable manner.

According to important guidelines of the Country such as the "14th Five-Year Plan for Bioeconomy" and Key Tasks for Deepening the Reform of the Medical and Healthcare System in 2022. Sino Biopharma regards innovation and transformation as integral to its strategic development, and is focused on four main therapeutic areas: oncology, hepatitis, respiratory, and surgery/ analgesia. It has been mapping out innovative drug projects with best-in-class (BIC) and first-in-class (FIC) potential, and is driving innovative development through its dual engines: internal research and development, and commercial expansion. At present, the Group's innovation and transformation have entered the harvest stage. In the next three years, more than 10 innovative drug products will be launched, and over 40 innovative drugs in the pipeline may be launched by 2030, further promoting the high-quality development of the Group, realizing the revenue target of HK$100 billion by 2030, and becoming a leading innovative pharmaceutical group in the world. In addition, as the cornerstone of generic drugs, the Group will continue to deploy special generic drugs that have broad market prospects and are highly competitive, and through efficient and stable production maintain steady revenue growth from generic drugs.

Under the four main strategies of "organizational integration, comprehensive innovation, internationalization, and digitalization", the Group will further consolidate resources, improve operational efficiency, accelerate and facilitate cooperation at home and abroad, and promote global innovation and development.

About Sino Biopharmaceutical Limited (HKEX:1177)
Sino Biopharmaceutical Limited is a leading, innovative R&D-driven pharmaceutical conglomerate in the PRC. Its business encompasses a fully-integrated chain which covers an array of R&D platforms, a line-up of intelligent production and a strong sales system. The Group's products have gained a competitive foothold in various therapeutic categories with promising potential, comprising a variety of biopharmaceutical and chemical medicines for tumors, liver diseases, respiratory system diseases and surgery/analgesia.

Sino Biopharma is a constituent stock of the following indices: MSCI Global Standard Indices – MSCI China Index, Hang Seng Index, Hang Seng China Enterprises Index, Hang Seng Composite Index, Hang Seng Healthcare Index, Hang Seng SCHK Mainland China Healthcare Index, Hang Seng Composite LargeCap Index, Hang Seng Composite LargeCap & MidCap Index, Hang Seng China (Hong Kong-listed) 100 Index and Hang Seng Stock Connect Hong Kong Index, etc. Sino Biopharm was ranked as one of "Asia's Fab 50 Companies" by Forbes Asia for three consecutive years in 2016, 2017 and 2018.

For more information:
Strategic Financial Relations Limited
Vicky Lee +852 2864 4834 vicky.lee@sprg.com.hk
Sophie Du +852 2864 4815 sophie.du@sprg.com.hk
Website: www.sprg.com.hk


Copyright 2023 ACN Newswire. All rights reserved. http://www.acnnewswire.com

ACROMETA Signs Sales & Purchase Agreement for Additional 40% of Life Science Incubator

SINGAPORE, Mar 31, 2023 – (ACN Newswire) – ACROMETA Group Limited, an established specialist engineering service provider in the field of controlled environments serving mainly the healthcare, biotechnology, pharmaceutical, research and academia sectors, has entered into a Sales and Purchase Agreement ("the Agreement") for an additional 40% of the outstanding shares of Life Sciences Incubator Pte Ltd ("LSI") for a total consideration of S$1.6 million payable in tranches, based on the realisation of agreed milestones in its immediate expansion plan. Upon completion of the purchase, the Group will control 70% of LSI, up from the current 30%.

The Agreement updates and follows from the Letter of Intent ("LOI") announced to SGXNet on 20 February 2023 for the proposed acquisition of an additional 40% stake in LSI.

A site visit to Brisbane and the due diligence carried out by ACROMETA Management have shortlisted the location of the proposed co-working laboratory in Australia as it found it suitable.

Mr Levin Lee Keng Weng, ACROMETA Chairman, said, "Brisbane is a booming hub for the Life Sciences sector in Australia. According to Global Australia[1], a government-industry development agency, Queensland is home to more than 250 life sciences organisations, 85 core biotech companies, and more than 100 biotech-related research organisations.

A whole ecosystem has emerged with clusters of dynamic and innovative SMEs and start-ups either conducting their R&D or supporting the multinationals and research centres focusing on biotechnology, pharmaceuticals, medical devices and specialist healthcare such as gerontology and neurology."

Mr Lee added, "The demand for co-working laboratory space is strong. The performance milestones for the payment in tranches agreed to by the Vendor indicate that both the Purchaser and the Vendor have confidence in the co-working laboratory business in Australia and Singapore.

The proposed additional co-working laboratory space in Singapore is to cater for expected growth in demand. In addition, as Singapore transforms its economy towards high-value sectors, more and more SMEs and start-ups conducting their R & D will require co-working laboratory space."

This Media Release is to be read in conjunction with the announcement on SGXNet on 31 March 2023.

[1] https://www.globalaustralia.gov.au/industries/health-and-life-sciences

About ACROMETA Group Limited (SGX Stock Code:43F)

ACROMETA (Previously known as ACROMEC Limited) is an established specialist engineering services provider with more than 25 years of experience in the field of controlled environments.

The Group has, over the years, acquired expertise in the design and construction of facilities requiring controlled environments such as laboratories, medical and sterile facilities and cleanrooms.

ACROMETA's business is divided into three main business segments: (i) Engineering, procurement, and construction services, specialising in architectural, and mechanical, electrical, and process works within controlled environments; (ii) Maintenance and repair services of facilities and equipment of controlled environments and their supporting infrastructure. (iii) Co-Working Laboratory business; currently operates a 6,500 sq feet co-working laboratory space at The German Centre in Singapore serving SMEs and start-ups.

The Group mainly serves the healthcare, biotechnology, pharmaceutical, research and academia, and electronics sectors. ACROMETA's customers include hospitals and medical centres, government agencies, research and development companies or agencies, research and development units of multinational corporations, tertiary educational institutions, pharmaceutical companies, semiconductor manufacturing companies, and multinational engineering companies.

The Company has been listed on the Catalist board of the Singapore Exchange since 2016. For more information, please visit www.acrometa.com

Media and Analysts Contact:

ACROMETA Group Limited
Mr. Jerry Tan
Chief Financial Officer
Tel: +65 6415 0574
Email: jerry.tan@acromec.com

Waterbrooks Consultants Pte Ltd
Mr. Wayne Koo
Tel: +65 6958 8008 / +65 9338 8166
Email: wayne.koo@waterbrooks.com.sg
Email: query@waterbrooks.com.sg

This media release has been reviewed by the Company's sponsor, Evolve Capital Advisory Private Limited (the "Sponsor"). It has not been examined or approved by the Singapore Exchange Securities Trading Limited (the "Exchange"), and the Exchange assumes no responsibility for the contents of this document, including the correctness of any of the statements or opinions made or reports contained in this document.

The contact person for the Sponsor is Mr. Jerry Chua, 138 Robinson Road, #13-02 Oxley Tower, Singapore 068906, jerrychua@evolvecapitalasia.com

Copyright 2023 ACN Newswire. All rights reserved. http://www.acnnewswire.com

Austar Lifesciences Announces 2022 Annual Results

HONG KONG, Mar 31, 2023 – (ACN Newswire) – Austar Lifesciences Limited ("AUSTAR" or "Company") (HKEX Stock Code: 6118.HK), a technology-based pharmaceutical engineering solution provider, together with its subsidiaries (collectively the "Group" or "AUSTAR Group"), announced its audited annual results for the year ended 31 December 2022 ("Reporting Period"). Although the Group was affected by the requirements for epidemic control causing challenges to its supply chain, manufacturing, and project execution, the Group recorded a growth of approximately 10.6% in revenue as compared to the corresponding period in 2021. Thanks to the Group's capacities to offer modular and innovative solutions with digitalisation and robotic technologies based on excellent containment-based engineering and contamination control practices, the Group's product lines in the sectors of active pharmaceutical ingredients (API) and oral solid dosage (OSD) in chemical drugs have still been recorded a significant growth in order-in-take and revenue.

RESULTS OF OPERATIONS BY BUSINESS SEGMENT

Liquid and Bioprocess System
During the Reporting Period, through effective management of supply chain and project execution, the Group's revenue from the business segment of Liquid and Bioprocess System increased from 2021 by approximately RMB67.3 million or 7.6% to approximately RMB950.3 million for the Reporting Period. With completion of construction of a production site, this business segment is believed to have upgraded its manufacturing condition, with more space for new product research and development and more optimised production processes, which will definitely improve its competitiveness in terms of cost efficiency and quality standard.

Clean Room and Automation Control and Monitoring System
The Group's revenue from the business segment of Clean Room and Automation Control and Monitoring System increased from 2021 by approximately RMB34.4 million or 7.2% to approximately RMB514.1 million for the Reporting Period. The revenue increased along with that of order-in-take due to ever increasing market potential and recognition of the Group in the market in terms of technology and execution efficiency. The Group has been gaining good market reputation and share, with new technology of integrated space sterilisation system, dust particle online monitoring, floating bacteria monitoring, energy saving control and etc., which provides customers with computerised system confirmation and validation documents, and cost-effective solution. The fast growth of research and development for innovative drugs in mainland China had led to a much larger demand for the business of this segment, with a higher requirement on quality, cost efficiency, and effective project execution. On top of that, with the emerging innovative medical treatment, more capital is pursuing cell therapy commercial production. All these trends constitute a huge business opportunity for the Group, as a knowledge and technology leader in this area.

Powder and Solid System
The Group's revenue from the business segment of Powder and Solid System increased dramatically from 2021 by approximately RMB107.5 million or 77.7% to approximately RMB245.8 million for the Reporting Period. The revenue of this business segment has been increasing constantly, due to enlarged market share of the Group by dedicated investment of new products. The increase in revenue was in line with that of order-in-take and the increased backlog balance at the end of 2021 also contributed to this growth. The Group's adoption of modular design increases the flexibility of products, which was well acknowledged by the market and thus drove the business increase, to a large extent. At the same time, the business potential, in terms of market share and technical advantage, was greatly enlarged with integration of material and formula management system, integrated process equipment, automatic equipment, including automatic transfer equipment, robots and automatic guided vehicles (AGV), and etc.

GMP Compliance Service
The Group's revenue from the business segment of GMP Compliance Service increased significantly from 2021 by approximately RMB28.2 million or 42.7% to RMB94.3 million for the Reporting Period. The business revenue of this segment has been increasing constantly attributable to the new business stimulated by new international standards and other requirements. Along with its business scope extension to the entire life cycle of pharmaceutical production process, GMP Compliance Service is believed to keep pace of a rapid growth in the future.

Life Science Consumables
The Group's revenue from the business segment of Life Science Consumables decreased by approximately RMB32.8 million or 7.8% to approximately RMB388.3 million for the Reporting Period as compared to 2021. The decrease in revenue was caused by the decline from the business related to COVID-19 vaccine production. The Group is investing into the area of sterile chemical drugs and cell therapy, which is believed to be a new business and profit margin generator in the revised long-term business strategy.

Distribution and Agency of Pharmaceutical Equipment
The Group's revenue from the business segment of Distribution and Agency of Pharmaceutical Equipment increased by approximately RMB8.9 million or 33.2% to approximately RMB35.8 million for the Reporting Period as compared to 2021. The Group will continue to engage in the distribution of various types of high-end pharmaceutical equipment together with its joint ventures and overseas business partners providing clients with the most intimate and timely service.

Research and Development, and Production Lines
With regards to the research and development, the Group obtained 384 patents. During the Reporting Period, the Group obtained 76 registered patents, and applications for 83 patents are currently in progress. Based on the SIEMENS software platform, a report system about Utility Automation System and Process Control system was developed in 2022, which improves the automation system functions and shortens the research and development period of projects. The Group developed a data analysis system, through a series of mathematical algorithms to achieve multivariate data analysis and prediction and help clients achieve analysis and prediction in the process of biological reaction, which could be used at both research and commercial manufacturing phases of the client's product lifecycle.

In addition, the Group's stainless-steel bioreactor series entered the stage of large-scale manufacturing and execution in 2022. The inline conditioning system ILC based on process analytical technology (PAT) developed in 2021 has completed the comprehensive upgrade of recipe management and control system and has been trialed by target clients. It is expected to achieve a breakthrough in 2023.

The Group has completed the development of cell preparation isolator and cell culture system at the end of 2022. This development achievement supplemented AUSTAR's ability in cell therapy process system and services, and increased brand recognition in the field of Advanced Therapy Medicinal Products (ATMP).

AUSTAR's management said, "The Group has been developing 12 technology applications in our competence and knowledge model, and individual specific technology application teams have been established step by step over the past years. The Group has set up 12 technology application teams, namely: (1) Pharmaceutical Automation & Digitalization, (2) Cleaning, Sterilization & Disinfection, (3) Clean Utilities, (4) Biopharma Process and Technology, (5) Containment Technology, (6) Clean Room/HVAC/EMS/BMS, (7) Freeze-drying, Filling & Inspection, (8) Biosafety Technology and Facilities, (9) Laboratory Technology & Facilities, (10) Pharmaceutical Formulation Technology, (11) Regulatory Compliance & Operation Excellence, and (12) Analytics Measurement Technologies, where regular workshops were held for the purpose of better unification of the technology capability of individual product lines into comprehensive technology solutions."

Exploring Business Growth Drivers through Acquisitions
During the Reporting Period, the Group continued to seek business growth through acquisitions. In February 2022, the Group successfully acquired the business of an expertise in sterile liquid and powder filling line ("BOSTA Business"), which has further enhanced the Group's business portfolio in the integration of the filling line system and freeze-dryer system and increased the capability of providing integrated solutions for the filling and freeze-drying of aseptic products. In 2022, the Group also successfully completed the acquisition of a minority shareholding of a company which provides complete and high-end solutions used in nanomedicine and inhalation preparations. It is expected that the Group and the said company are able to benefit from this transaction through upcoming strategic business collaboration.

Future Growth Drivers
Looking forward, with the rapid development trend of cell and gene therapy sector, Car-T drugs were approved, which represents that the ATMP products has entered the stage of rapid development. The Group is dedicated to helping clients to build a compliant, lean and flexible cell therapy facilities, providing engineering and process solutions from conceptual design, clean engineering to core cell therapy process equipment, and building traceable cell therapy automation and information solutions. More cell-related equipment and systems in the ATMP sector would be launched in 2023 including some products developed and manufactured by the Company with its own intellectual property rights. Strong pipelines of products and services under development through the corporate level Innovative and Research Centre and through business unit research and development teams can support further growth in the Group's business.

To improve the quality and yield of drugs, API manufacturers are paying more attention to advanced technologies such as continuous-flow micro-reactions, continuous crystallisation and crystal form control, and process analysis in the production process to increase the stability of drugs in order to increase the market share through new technologies. This will further promote the digitalisation transformation of API companies. Our clients' business extension from formulations to API manufacturing, and their business extension from existing API to formulations manufacturing, was one of the key trends of pharmaceutical industry development in China in 2022. Modular design application reduces production cost and improves operation flexibility, which has successfully helped securing orders. This modular technology would be one of the key technologies for API manufacturing in the coming years.

Moreover, the core competence of the Group's Powder and Solid system engineering business would be accelerated by its application of automated devices like robots and AGV integrated by automation control system together with customised production information system. Demand from some emerging countries for establishment of API facilities and chemical compound product technology transfer as supply chain back-up and cost pressure will further drive growth in this business segment.

Due to the release and enforcement of EU GMP new regulations and process requirements of cell and gene therapy, the sterility assurance in the whole manufacturing process become stringent and key considerations in equipment and system engineering. It is believed that with AUSTAR UK, Cape Europe Joint Venture in France and the Group's manufacturing facility for sterile transfer and isolation technology in China working closely with a strategic goal to offer most competitive sterile protection and assurance scheme globally, it will contribute substantial growth in revenue and profit to the Group."

About Austar Lifesciences Limited
Founded in 1991 and headquartered in Shanghai, PRC, AUSTAR is a technology-based pharmaceutical engineering solutions provider with its business covering more than 50 countries and regions, partnering with world-leading pharmaceutical companies to protect and promote human health. AUSTAR employs approximately 2,000 staff in different regions to deliver technically guaranteed pharmaceutical engineering solutions that assist clients to set up drug production facilities and contribute to the world's drug safety and efficacy.

With the full spectrum of pharmaceutical technology knowledge, the company has leading technical application capabilities and high-quality equipment & systems in the areas of Clean Utilities, Pharmaceutical Automation & Digitalization, Pharmaceutical Formulation Technology, Biopharma Process & Technology, Regulatory Compliance & Operation Excellence, Laboratory Technology & Facilities, Biosafety Technology & Facilities, Cleaning, Sterilization & Disinfection, Clean Room/HVAC/EMS/BMS, Quality/Measurement & Analytics, Filling, Freeze-Drying & Inspection, Containment Technology. The Group has a number of leading business and product brands in its portfolio including H+E Pharma, BIOSYSTEC, STERIS-AUSTAR, ROTA-AUSTAR, Pharma LeanTec, Pharma LeanDigital, AUSMILL, Aunity, and Purvita. AUSTAR was listed on the Main Board of the Stock Exchange of Hong Kong Limited on 7 November 2014 (Stock code: 6118).

For more information about AUSTAR, please visit www.austar.com.cn


Copyright 2023 ACN Newswire. All rights reserved. http://www.acnnewswire.com

Rxilient Biotech and Junshi Biosciences form Joint Venture to develop and commercialize Toripalimab in Southeast Asia

HONG KONG, Mar 31, 2023 – (ACN Newswire) – On 28th March 2023, Rxilient Biotech (a portfolio company of Legend Capital) and Junshi Biosciences made a joint announcement that two parties will form a joint venture to develop and commercialize toripalimab in Thailand, Brunei, Cambodia, Indonesia, Laos, Malaysia, Myanmar, the Philippines, and Vietnam[1].


From left to right: CEO of Junshi Biosciences, Dr. Li Ning; Managing Director of Legend Capital, Executive Director of Rxilient, Mr. Hong Tan; Chairman, Chief Executive and President of CMS, Mr. Lam Kong; Chairman of Junshi Biosciences, Mr. Xiong Jun; CEO of Rxilient, Dr. Lee Ker Yin


Toripalimab is an anti-PD-1 monoclonal antibody independently developed by Junshi Biosciences. Junshi Biosciences has conducted over 30 clinical trials globally (in China, the USA, Southeast Asia, and Europe) covering more than 15 indications, including cancers of the lung, nasopharynx, esophagus, stomach, bladder, breast, liver, kidney, and skin. Six of these indications have been approved in China, and multiple marketing applications are currently under review by regulatory agencies in the US, EU, and UK.

"Cancer patients need toripalimab. We are confident that the highly professional and experienced Rxilient team will drive quick access to this valuable drug, toripalimab to patients in Southeast Asia," said Mr. HONG Tan, MD of Legend Capital.

"This collaboration is a good case example of Chinese pharmaceutical companies venturing overseas to help improve access to important novel drugs in emerging markets. Southeast Asia has a thriving innovative pharmaceuticals market, harmonized drug registration system, and diversified healthcare systems. Hence, it has great potential for innovative drugs. Legend Capital will continue to pay attention to investment opportunities in the healthcare industry of Southeast Asia, actively promote and assist Chinese pharmaceutical companies to enter the international markets, thus facilitating innovative drugs from China to benefit patients around the world," said Mr. HONG Tan.

Through this collaboration, Rxilient will introduce Toripalimab, a novel anti-PD-1 monoclonal antibody, into Southeast Asia. This joint venture leverages the strengths of Rxilient and Junshi Biosciences in drug registration and commercialization, and the R&D capabilities respectively. Rxilient plans to continue collaboration with Junshi Biosciences to introduce more high-quality innovative drugs into Southeast Asia.

JUNSHI BIOSCIENCES
Founded in December 2012, Junshi Biosciences (HKEX: 1877; SSE: 688180) is an innovation-driven biopharmaceutical company dedicated to the discovery, development, and commercialization of innovative therapeutics. The company has established a diversified R&D pipeline comprising over 50 drug candidates, with five therapeutic focus areas covering cancer, autoimmune, metabolic, neurological, and infectious diseases. Junshi Biosciences was the first Chinese pharmaceutical company that obtained marketing approval for anti-PD-1 monoclonal antibody in China. Its first-in-human anti-BTLA monoclonal antibody for the treatment of various cancers was the first in the world to be approved for clinical trials by the FDA and NMPA and has since entered Phase Ib/II trials in both China and the US. Its anti-PCSK9 monoclonal antibody was the first in China to be approved for clinical trials by the NMPA.

RXILIENT
Rxilient Biotech, established in November 2021, is a subsidiary controlled by China Medical System Holdings Limited ("CMS", (00867.HK)). Rxilient Biotech and other companies related to CMS that are involved in Southeast Asian businesses (together with Rxilient Biotech, "Rxilient", promoted and cofounded by CMS and Legend Capital) have formed an open platform integrating innovative R&D, formulation contract development, and manufacturing organization (CDMO), manufacturing, marketing, and promotion. Leveraging CMS's capability in acquiring high-quality products and strong financial position, Rxilient aims to bring innovative solutions from leading pharmaceutical companies in the USA, Europe, Japan, and China, to meet medical needs in Southeast Asia. Rxilient is operated independently by professional and experienced local teams in Southeast Asia.

[1] Junshi Biosciences's related license to the joint venture is subject to the fulfillment of the conditions precedent as agreed under the Shareholders Agreement.


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Yunkang Group Announces First Annual Results Since Listing

HONG KONG, Mar 31, 2023 – (ACN Newswire) – Yunkang Group Limited ("Yunkang" or the "Group"; Stock Code: 2325), a leading medical operation services provider in China, has announced its first annual results for the year ended December 31, 2022 (the "Reporting Period") since its listing.

Driven by the promotion of health care policies in mainland China, the Group has made steady progress in service network expansion, operational efficiency improvement and lean management, and achieved quality growth under the annual goals of "in-depth service, lean management and achieving quality growth". In particular, in the field of diagnostic testing services for medical institution alliances, the Group has developed a set of medical institution alliance construction and operation support solutions with the advantages of "professionalism, standardization and intelligence", which effectively enhanced the diagnostic capabilities and service efficiency of medical institution alliances and continued to have a positive impact on the Group's profitability. During the Reporting Period, the Group's revenue reached RMB3,756 million, representing a year-on-year increase of 121.4%, and its gross profit increased by 45.4% to RMB1,307 million. Profit attributable to owners of the Company reached RMB377 million for the year. The Board of Directors resolved to recommend the payment of a final dividend of HK$ 0.22 per share for the year ended December 31, 2022.

Three main businesses maintained rapid growth with in-depth services
The Group achieved rapid growth in scale in the provision of diagnostic testing services for medical institution alliances. During the Reporting Period, revenue generated from this segment reached RMB1,680 million, representing an increase of 171.3% compared with the same period in 2021. The number of on-site diagnostic centers increased from 275 as of December 31, 2021 to 398 as of December 31, 2022, providing over 840 medical institutions with diagnostic testing services for medical institution alliances and helping medical institutions enhance diagnostic testing capabilities at all levels in the medical institution alliances and improve the efficiency of diagnostic testing services as a whole. The expansion of capabilities and service scope of on-site diagnostic centers after the initial construction and operation, resulting in a rapid growth of 90.9% in the average revenue of the unit on-site diagnostic centers to RMB 4.2 million. As a key business for the Group, diagnostic testing services for medical institution alliances accounted for an increasing proportion of the Group's total revenue, rising from 36.5% for the year ended December 31, 2021 to 44.7% for the year ended December 31, 2022.

During the Reporting Period, revenue from diagnostic outsourcing services amounted to RMB1,944 million, a growth of 89.8% when compared with the same period of 2021. The Group's product lines in key areas such as infectious diseases and blood diseases maintained stable growth during the Reporting Period, driving further growth in outsourcing services revenue. As a professional medical diagnostic testing service institution, the Group has continuously improved its diagnostic testing capabilities and developed competitive products to provide customers with more precise medical solutions. It has established nearly 10 new provincial comprehensive laboratories and regional rapid response laboratories in order to respond to customer demands more quickly and efficiently.

Diagnostic testing services for non-medical institutions are mainly provided through the Group's outpatient clinics, serving the general public and other individual customers such as employees of the Group's non-medical institution clients. During the Reporting Period, due to the impact of the COVID-19 pandemic, the demand for COVID-19 testing from individual customers and non-healthcare customers increased significantly, and the diagnostic testing services for non-medical institutions recorded revenue of RMB131.5 million, representing a growth of 147.5% compared with the same period of 2021.

Expand network to guide the allocation of quality medical resources to move downwards
The Group has basically built four models for the development of medical institution alliances, namely urban medical institution alliances, county-level medical alliances, specialist alliances and telemedicine collaboration networks, and has matched them with specific schemes to create various iconic joint projects and help to guide the sharing and allocation of quality medical resources to move downwards, so as to enhance the service capabilities of medical institutions at all levels.

Pursue technological innovation to improve precision diagnostic technology
During the Reporting Period, the Group embarked on a number of domestic and international industrial collaborations in pursuit of an internationally competitive industry position. In 2022, the Company's investment in R&D reached RMB94.7 million, accounting for representing a year-on-year increase of 115.6%. Through external cooperation, the Group continued to develop in a healthy manner and offer competitive products and services to the market.

Achieve lean operations to strengthen operational capabilities
During the Reporting Period, the Group's laboratory lean operation project achieved initial results. The lean operation project mainly consists of two parts, namely the 7S management of self-built labs and the establishment of a management system for collaborative projects.

Digitalization of operations to establish a standardized operation system
In terms of digitalization, the Group successively launched 10 digital operation systems, including "Tengyun", in 2022, to fully integrate the Group's sales management system, human resources system, training system, settlement system, general ledger system, fixed asset system, warehousing system, logistics system and customer service system. Consequently, Yunkang's digital operation model has taken shape.

Prioritizing quality to raise product and service standards
By adhering to the strategic concept of "Quality is the lifeline", the Group has actively promoted the lean management of production and operation, established world-leading laboratories that meet international standards and continuously improved product quality and service quality to provide customers with professional, precision, efficient and convenient medical and health services. As one of the first medical service companies to establish medical laboratories that meet international standards, the Group has built independent medical laboratories with ISO15189 quality control system certification and CAP dual certification in Southern, Eastern and Southwestern China. As at the end of the Reporting Period, the Group had obtained various domestic and overseas quality certifications, including CAP, ISO15189, ISO9001, CMA, CMMI and ISO27001, of which the Guangzhou laboratory has even obtained the ISO15189 certification for 12 consecutive years.

Mr. Zhang Yong, Chairman and Executive Director of Yunkang Group Limited, said, "The overall demand for public health services from the public has become stronger after the COVID-19 pandemic. This, coupled with the aging population, has led to increased health awareness and demand for health services among the public. In light of this, the government has introduced a series of policies to promote the upgrading of medical service demand and the four models for the construction of medical institution alliances, namely urban medical groups, county-level medical alliances, specialist alliances and telemedicine collaboration networks. On the technology side, the rapid development of biotechnology has facilitated the expansion of the bioeconomy into many other sectors. Driven by multiple favorable factors, the universal health care industry, especially the third-party testing sector, which places high emphasis on quality, cost and efficiency, is bound to see tremendous development opportunities. Looking ahead, the Group will continue to execute "in-depth service and lean management" to enhance its products and co-built solutions through in-depth service marketing; supported by a lean operation system, it will continuously enrich its in-depth service content and optimize the cost structure of the entire value chain. The Group will continue to leverage on its own value, committed to improving people's livelihood and health, and striving to provide more professional, accurate, efficient and convenient medical and health testing services to the medical institutions and general public."

Yunkang Group Limited (Stock Code: 2325)
Yunkang Group is a leading medical operation service provider in China, which started to provide standardized medical diagnostic services to medical institutions at all levels as early as 2008. Leveraging its own professional diagnostic capabilities and the nationwide service network of integrated healthcare systems, Yunkang has gradually grown to become a medical operation service platform. Meanwhile, Yunkang is a medical operation service provider in China offering a full suite of diagnostic testing services which are diagnostic outsourcing services and diagnostic testing services for medical institution alliances. Yunkang provides diagnostic services through on-site diagnostic centers to collaborative hospitals in the integrated healthcare systems in China, and assists them in improving their clinical diagnosis capabilities through co-developing diagnostic centers. As of December 31, 2022, Yunkang has successfully provided professional services to 398 medical institution alliances and the hospitals we collaborated with were located across 31 provinces and municipalities in China.

Media Enquiries
Yunkang Group Ltd
Venus Zhao General Manager of Hong Kong Office, General Manager of Capital Markets and Corporate Communication
E-mail: zhaohui@yunkanghealth.com
Website: www.yunkanghealth.com

Strategic Financial Relations Limited
Angelus Lau / Yan Li / Holly Szeto
Tel: 2864 4805 / 2114 4320 / 2864 4859
E-mail: angelus.lau@sprg.com.hk / yan.li@sprg.com.hk / holly.szeto@sprg.com.hk
Website: www.sprg.com.hk


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Ocumension Therapeutics Announces 2022 Annual Results

HONG KONG, Mar 30, 2023 – (ACN Newswire) – Ocumension Therapeutics ("Ocumension" or the "Company", together with its subsidiaries, collectively the "Group", stock code: 1477), a leading China ophthalmic pharmaceutical platform company, announced its annual results for the year ended 31 December 2022 today.

2022 was a year full of challenges and opportunities which the Company survived the ups and downs of the COVID-19. Courageous without hesitations is always the mission Ocumension Therapeutics committed to stick with. Given that, the Group achieved remarkable results during the year. It was attributable to the successful commercialization of multiple companies' core products which boosted the sale, plus the increase of revenue generated from the sales of ophthalmic products. During the year, operating revenue surged 183.1% to RMB159.0 million, as compared to RMB56.1 million in 2021. Consolidated gross profit margins was approximately 64.7%, total R&D expenses for the year amounted to RMB184.3 million, an increase of 9.0% as compared to 2021. Loss for the year attributable to the owners of the company was RMB402.6 million, mainly because no one-time gain was generated from the transaction with third parties, and the increase in share-based payments which the Group has further granted options, awards and RSUs under the share incentive schemes to our employees and consultant during the Reporting Period.

The Group continued to accelerate the penetration of the drugs in hospitals in the PRC ophthalmology market, achieving a coverage of 8,171 hospitals nationwide, 1,384 of which are Grade III hospitals, and a commercialization team of 191 people, thereby having completed the national commercialize network coverage. During the Reporting Period, the sales of Ou Qin and Emadine increased by 64% and 199%, respectively, as compared to the year ended December 31, 2021.

The Group continued to promote research and development progress during the year, the NDA for the Company's Core Product, Youshiying (OT-401), was approved by the NMPA in June 2022 for the treatment of chronic NIU-PS and commercialization in the PRC, ahead of the expected schedule. Youshiying was subsequently launched officially in December 2022 and completed the first patient injection, this is the first drug approved in China fully based on real-world study data and overseas clinical data, marked a milestone achievement in the history of drug registration in China and demonstrated the Company's research and development capabilities. At the same time, which in turn is also expected to boost the sales performance of the Company in 2023.

In addition, the phase III clinical trial of ZERVIATE (OT-1001), a potent and highly selective histamine-1 receptor antagonist with anti-allergic properties, has achieved its primary clinical endpoint and received positive results. The Company received approval from CDE for the phase III clinical trial of ILUVIEN (OT-703) for the treatment of diabetic macular edema (DME), having increased the total number of drug candidates in the stage of phase III clinical trial to six, giving the Company a significant lead over other competitors. OT-202 being one of the in-house developed new chemical entity (NCE) ophthalmic drugs with whole new targets and the fastest clinical progress in China for many years has drawn extensive attention from the medical community. As of now, the Company has successfully completed the phase I clinical trial of OT-202, and has initiated its phase II clinical trial on a researcher conference. The smooth progression of the project OT-202 served as concrete proof of the Company's solid innovation and research and development capabilities.

The research and development of the other pipeline products of the Company has also been continuously advancing in 2022. The completion of patients enrollment in China for the global phase III clinical trial of OT-101 (0.01% atropine sulfate eye drop), a self-developed new drug to treat the progression of myopia, signified the achievement of the milestone event of OT-101, which is expected to greatly accelerate the R&D and registration process of the such drug candidate, enabling patients in China suffering from myopia to have the opportunities to receive timely treatment.

The Company has established a comprehensive marketing and promotion system within the year. With the support of the system, Ocumension has met its aggregated sales goal of revenue of over RMB100 million in the fourth year since its inception. Meanwhile, the Company's sales efficiency has also further improved. Benefitting from its powerful commercialization network in the field of ophthalmic drugs, During the Reporting Period, the Company obtained the promotion right of all the ophthalmic pipeline products of Viatris in the hospitals nationwide in the PRC, further fortifying its leading position in the key fields such as glaucoma and antiallergy in the PRC, as well as increasing the number of commercialized pipeline products of the Company to 14.

Besides, our Suzhou manufacture site started pilot-scale and process validation batch production in May 2022. With the highly automated production lines, the production standard of our Suzhou manufacture site was able to reach the world-class manufacturing level and thus to ensure the quality and production efficiency of the products of the Company. The inauguration and start of operation of our Suzhou Xiaxiang manufacture site have not only firmly assured the Company's further improvement in sales, cost reduction, stable supply and enhanced profitability, but also demonstrated the manufacturing capabilities of the Company, lay a solid foundation for potential opportunities for international cooperation on the production of drug products in the future.

Looking forward to 2023, the Company will further advance and accelerate the process for registration and commercialization of the drug candidates under research and development, introduce more in-house developed products into clinical trial stage and maintain a wholesome product portfolio, so as to sustain its leadership among the peers in terms of the product pipeline. Pivoting the launch of the Core Product, Youshiying, the Company's commercialization team will further widen the scope and deepen the level of its promotion in the academic aspect, and strive to maintain the Company's exponential growth in sales.

In terms of research and development, at least two new products of the Company will enter the registration stage in 2023, keeping the pace of the continuous launch of new products. In terms of manufacture and production, our Suzhou Xiaxiang manufacture site will achieve commercialized mass production to ensure the stability of supply and the quality of products. At the same time, as the team stability and cohesion were finally achieved, be committed to building a unique corporate culture catering to Ocumension to safeguard our sustainable development and growth in the next stage in 2023.

Mr. Ye LIU, CEO and Executive Director of Ocumension, said: "As a young biopharma, Ocumension is marching into the fifth year since its inception. Leveraging the ameliorative market trend and favorable business environment in 2023, the Company will continue to grow at an exceptional pace as a pioneer, so as to repay the Shareholders' trust in and support to the Company. "

About Ocumension Therapeutics
Ocumension Therapeutics is a Chinese ophthalmology platform company dedicated to identifying, developing and commercializing pioneering or best-in-class ophthalmic therapies. The company's vision is to provide world-class drug solutions to meet the huge demand for ophthalmology treatments in China. We believe that our ophthalmology platform with its obvious first-mover advantage will give us a leading position in the ophthalmology industry in China. Up to now, the company has 24 kinds of drug assets in front of the eye and back of the eye, and has established a complete ophthalmic drug product line, six of which have entered phase III clinical trials in China. On July 10, 2020, Ocumension was listed on the main board of the Stock Exchange of Hong Kong Limited (stock code: 01477).

More information about Ocumension Therapeutics: https://www.ocumension.com/


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Apollomics, a Company Developing Novel Oncology Therapies to Address Difficult-to-Treat Cancers, Announces Closing of Business Combination and Listing on Nasdaq

FOSTER CITY, Calif., Mar 30, 2023 – (ACN Newswire) – Apollomics Inc. ("Apollomics" or the "Company"), a clinical-stage biopharmaceutical company developing multiple oncology drug candidates to address difficult-to-treat and treatment-resistant cancers, today announced the completion of its business combination (the "Business Combination") with Maxpro Capital Acquisition Corp. ("Maxpro", Nasdaq: JMAC). Apollomics' Class A ordinary shares and public warrants are expected to commence trading today, March 30, 2023, on the Nasdaq Capital Market (Nasdaq) under the symbols "APLM" and "APLMW," respectively. The Business Combination, which was approved by Maxpro's shareholders on March 20, 2023, along with a $23.65 million private investment in public equity (PIPE) financing raised in connection with the Business Combination, provides access to capital that is expected to enable the Company to advance its pipeline of drug candidates.

Apollomics' mission is to improve treatment options for patients diagnosed with difficult-to-treat, high mortality cancers. Apollomics' pipeline includes nine novel oncology drug candidates, six of which are currently in clinical stage of development. By using targeted therapy, immuno-oncology agents, and other innovative approaches, Apollomics' novel drug candidates have the potential to address a range of cancers, including lung cancer, brain cancer, acute myeloid leukemia, and other solid tumors.

Apollomics expects results from its global Phase 2 multi-cohort clinical trial of vebreltinib (APL-101), a highly specific cMet inhibitor, in non-small cell lung cancer and other solid tumors with cMet dysregulation, this year, which the Company believes may support its first new drug application with the U.S. Food and Drug Administration (FDA) while generating clinical data on other indications. Apollomics is also developing uproleselan (APL-106), an E-selectin inhibitor, in China as an adjunct to chemotherapy to enhance its anti-cancer effects for adult patients with relapsed or refractory acute myeloid leukemia. The FDA granted Breakthrough Therapy Designation to GlycoMimetics, Apollomics' collaboration partner in the United States, for uproleselan, and the China National Medical Products Administration (NMPA) designated it as a breakthrough therapy in China. The Company expects to complete patient recruitment of its Phase 3 study for uproleselan (APL-106) in China this year.

"Becoming a public company represents a major milestone in our journey to provide solutions for patients with difficult-to-treat cancers worldwide," said Dr. Guo-Liang Yu, Ph.D., Chairman and Chief Executive Officer of Apollomics. "The funds now available to us are expected to facilitate development of our oncology pipeline and further our mission to provide patients with effective therapies and hope."

Moses Chen, Chief Executive Officer of Maxpro, said, "We are thrilled to have completed the Business Combination with Apollomics. We're confident that the Company's cutting-edge drug candidates will deliver value to investors while advancing the Company's ability to provide treatment options for patients diagnosed with difficult-to-treat, high mortality cancers."

Apollomics will continue to be led by Dr. Yu, a serial entrepreneur and pharmaceutical researcher with more than 300 patents, as its Chief Executive Officer and Chairman of the Board of Directors.

The Apollomics executive leadership team will also consist of:
— Dr. Sanjeev Redkar, Ph.D., MBA, Apollomics' Co-Founder, who will continue to serve as President and will serve as a Director;
— Dr. Jane Wang, Ph.D., who will continue to serve as Chief Scientific Officer; and
— Dr. Peony Yu, MD, who will continue to serve as Chief Medical Officer.

In addition to Dr. Yu and Dr. Redkar, Apollomics' Board of Directors will also consist of: Dr. Jonathan Wang, Ph.D., MBA; Dr. Kenneth C. Carter, Ph.D.; Dr. Hong-Jung (Moses) Chen, Ph.D.; Wendy Hayes, MBA; and Glenn S. Vraniak, MBA.

Advisors

EF Hutton, division of Benchmark Investments, LLC served as capital markets advisor and exclusive placement agent to Maxpro. Nelson Mullins Riley & Scarborough LLP served as legal advisor to Maxpro. White & Case LLP served as legal advisor to Apollomics.

About Apollomics Inc.

Apollomics Inc. is an innovative clinical-stage biopharmaceutical company focused on the discovery and development of oncology therapies with the potential to be combined with other treatment options to harness the immune system and target specific molecular pathways to inhibit cancer. Apollomics currently has a pipeline of nine drug candidates across multiple programs, six of which are currently in the clinical stage of development. Apollomics' lead programs include investigating its core product, vebreltinib (APL-101), a potent, selective c-Met inhibitor for the treatment of non-small cell lung cancer and other advanced tumors with c-Met alterations, which is currently in a Phase 2 multicohort clinical trial in the United States, and developing an anti-cancer enhancer drug candidate, uproleselan (APL-106), a specific E-Selectin antagonist that has the potential to be used adjunctively with standard chemotherapy to treat acute myeloid leukemia and other hematologic cancers, which is currently in Phase 1 and Phase 3 clinical trials in China.

Cautionary Statement Regarding Forward-Looking Statements

This press release includes statements that constitute "forward-looking statements" within the meaning of the federal securities laws, including Section 27A of the Securities Act of 1933, as amended (the "Securities Act"), and Section 21E of the Securities Exchange Act of 1934, as amended (the "Exchange Act"). All statements, other than statements of present or historical fact included in this press release, regarding the Company's future financial performance, as well as the Company's strategy, future operations, revenue guidance, projected costs, prospects, plans and objectives of management are forward-looking statements. When used in this press release, the words "could," "should," "will," "may," "believe," "anticipate," "intend," "estimate," "expect," "project," the negative of such terms and other similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain such identifying words. These forward-looking statements are based on management's current expectations and assumptions about future events and are based on currently available information as to the outcome and timing of future events. Apollomics cautions you that these forward-looking statements are subject to numerous risks and uncertainties, most of which are difficult to predict and many of which are beyond the control of Apollomics. In addition, Apollomics cautions you that the forward-looking statements contained in this press release are subject to unknown risks, uncertainties and other factors, including: (i) the impact of any current or new government regulations in the United States and China affecting Apollomics' operations and the continued listing of Apollomics' securities; (ii) the inability to achieve successful clinical results or to obtain licensing of third-party intellectual property rights for future discovery and development of Apollomics' oncology projects; (iii) the failure to commercialize product candidates and achieve market acceptance of such product candidates; (iv) the failure to protect Apollomics' intellectual property; (v) breaches in data security; (vi) risks related to the ongoing COVID-19 pandemic and response; (vii) the risk that Apollomics may not be able to develop and maintain effective internal controls; (viii) unfavorable changes to the regulatory environment; and those risks and uncertainties discussed in the Form F-4 (as amended) filed by Apollomics, Inc. with the U.S. Securities and Exchange Commission ("SEC") under the heading "Risk Factors" and the other documents filed, or to be filed, by the Company with the SEC. Other unknown or unpredictable factors also could have material adverse effects on the Company's future results and/or could cause our actual results and financial condition to differ materially from those indicated in the forward-looking statements. Should one or more of the risks or uncertainties described in this press release materialize or should underlying assumptions prove incorrect, actual results and plans could differ materially from those expressed in any forward-looking statements. New risk factors that may affect actual results or outcomes emerge from time to time and it is not possible to predict all such risk factors, nor can Apollomics assess the impact of all such risk factors on its business, or the extent to which any factor or combination of factors may cause actual results to differ materially from those contained in any forward-looking statements. Forward-looking statements are not guarantees of performance. You should not put undue reliance on these statements, which speak only as of the date hereof. Additional information concerning these and other factors that may impact the operations and projections discussed herein can be found in the reports that Apollomics has filed and will file from time to time with the SEC. These SEC filings are available publicly on the SEC's website at www.sec.gov. Apollomics undertakes no obligation to update publicly any of these forward-looking statements to reflect actual results, new information or future events, changes in assumptions or changes in other factors affecting forward-looking statements, except to the extent required by applicable laws. If Apollomics updates one or more forward-looking statements, no inference should be drawn that Apollomics will make additional updates with respect to those or other forward-looking statements.

CONTACTS

Investor Relations
Peter Vozzo
ICR Westwicke
Peter.Vozzo@westwicke.com
443-213-0505

Media Relations
Sean Leous
ICR Westwicke
Sean.Leous@westwicke.com
646-866-4012


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Universal Medical (2666.HK) Announces 2022 Annual Results

HONG KONG, Mar 29, 2023 – (ACN Newswire) – Genertec Universal Medical Group Company Limited ("Universal Medical" or "Company"; Stock code: 2666.HK) is pleased to announce annual results for the year ended 31 December 2022.

In 2022, Universal Medical adhered to the "Healthy China" strategy and continued to expand its footprint in the healthcare sector. The continuous improvement in the core capacity of the hospital group, the gradual perfection of and breakthroughs in the footprint expansion of the specialty business and the health conglomerate's units, and the smooth and stable development of the finance business all contributed to the realization of the vision "To Be the Most Trusted Global Leader in Medical & Healthcare Services".

In 2022, the Company recorded a revenue of RMB11,912.1 million in total, up by 20.2% as compared to the previous year. In particular, the hospital group business recorded a revenue of RMB6,211.2 million, up by 34.8% as compared to the previous year, with its proportion to the total revenue increased to 52.1%; the Company recorded a profit for the year of RMB2,087.5 million, up by 2.8% as compared to the previous year, of which, the hospital group business contributed RMB378.3 million, up by 48.0% as compared to the previous year; the Company recorded a profit attributable to owners of the parent of RMB1,890.0 million, up by 3.0% as compared to the previous year; and the Company recorded a return on total assets (ROA) of 2.84% and a return on equity attributable to ordinary shareholders (ROE) of 13.96%. The indicators of income and the assets conditions maintained a steady and excellent performance.

-Central State-Owned Enterprises Improved Core Competitiveness, and the Net Profit Margin of The Medical Institutions Increased by 0.42 Percent

The medical institutions are not only the Company's core resources to build a healthcare conglomerate, but also the R&D and training center of its specialized medical business, as well as the project cultivation and commercialization pool and the sharing center for basic resources and practice of the industrial units. With respect to the integrated healthcare service segment, focusing on the development of the hospital group's core capacity, the Company continuously build up the competition advantages of central state-owned enterprises in running medical care by reinforcing group management and control and upgrading professional operation, so as to facilitate positive and continuous development of the state-owned hospitals and constantly improve operation efficiency and effectiveness.

In 2022, the consolidated Hospitals of SOEs contributed to the Company a revenue of RMB6,022.9 million, up by 37.2% as compared to the previous year; they recorded a profit for the year of RMB290.3 million in total, up by 50.2% as compared to the previous year; and the net profit margin was 4.82%, up by 0.42 percentage point from 4.40% of the previous year.

In 2022, the Company consolidated the accounts of seven additional medical institutions with a capacity of 3,357 beds in total; and the number of consolidated medical institutions as at 31 December 2022 increased to 55 (including 4 Grade III Class A hospitals and 26 Grade II hospitals), with a capacity of 13,615 beds in total. The number of beds of medical institutions that were included within the management system but not yet consolidated was over 2,000. The currently planned number of internally built beds exceeded 4,000 in total. In the future, based on the existing operation scale, the Company will continue to expand the scale of the hospital group through internal construction and mergers and acquisitions of/cooperation with external hospitals.

-Specialties and Healthcare Industry Created New Growth Drivers for the Listed Company with Solid Steps

With the business foundation and professional core talent team of its own hospital group, the Company strived to build replicable capabilities of specialties and industry operation while serving internal quality and efficiency enhancement, so as to create new growth drivers for the listed company. The financial contribution of this new business segment mainly comes from providing hospital clients with life cycle management of medical equipment and medical devises sales, which recorded a total revenue of RMB83.8 million in 2022 and a total profit of RMB8.6 million for the year.

Over the past year, the Company took solid steps in constructions of featured specialties such as nephrology and oncology as well as building core capabilities of the life cycle management of equipment. In addition, the Company has made various progress in the business layout of disciplines such as TCM, ophthalmology, stomatology as well as healthcare industry including Internet-based healthcare and health insurance.

As a listed company in the field of medical and healthcare, the Company strives to develop into a medical and healthcare conglomerate with financial service capabilities, featured specialty services and differentiated industrial business advantages, and gradually unleashes the value of its various business segments and assets. Looking forward, the Company will rely on the development foundation of the hospital group, and continue to build the industrial development foundation and team capabilities, with an aim to create more high-value profitable segments for the listed company while serving its member hospitals to reduce costs and increase efficiency.

-Finance Business Expanded Steadily and Earnings and Asset Quality Indicators Remained Excellent

As the continuous profit contributor of the Company, the finance business will always strive to maintain healthy and steady development while ensuring asset security, laying a solid foundation and cash cow for the sustainable development of the Company.

In 2022, faced with the complex economic situation, the Company always took risk control as a top priority, and were committed to ensuring quality project development for its customers. By keeping abreast of the market changes, the Company strived to arrange financing structure properly, so as to ensure liquidity security and reasonable financing cost control. The Company continued to optimise the dynamic management of pre-rental, rental, and post-rental process, and enhanced accountability to ensure its asset quality remaining at an industry-leading level while maintaining continuous and steady business expansion.

In 2022, the Company recorded income of finance business of RMB5,721.2 million in total, representing a year-on-year increase of 7.8%. The average yield of interest-earning assets was 7.22%, and the average cost rate of interest-bearing liabilities was 3.98%. The net interest spread was 3.24%, and the net interest margin was 3.67%. Its asset quality continued to remain excellent. As at 31 December 2022, the Company's net interest-earning assets reached RMB65,233.8 million, representing an increase of 6.7% as compared to that at the beginning of the year; the non-performing asset ratio was 0.99%; the overdue ratio (30 days) was 0.86%, and the provision coverage ratio was 263.11%.

Given that the domestic and international economy and financial markets continue to be confronted with many risks, challenges and uncertainties, Universal Medical will continue to promote the steady and safe development of its finance business, and give full play to the finance business to empower the development of the medical care industry, so as to lay a solid foundation for the high-quality development of a central state-owned and listed enterprise.

2023 marks a critical year for China market in its transition to the "post-pandemic" era, which also represents an important window period for the implementation of strategic initiatives of the Company. As a central state-owned and listed enterprise, the Company will continue to follow the overall deployment of the 14th Five-Year Plan and keep abreast of the latest development and requirements to promote steady development of the finance business, make strenuous efforts to improve the core capability and operating efficiency of the hospital group, accelerate the deployment of specialized disciplines and industry layout, and facilitate new breakthroughs in the high-quality development of the entire group, laying a solid foundation for the achievement of creating a more valuable listed company.

For further information, please contact:
PEANUT MEDIA LIMITED
Direct Line: +86-755-61619798 x8210
Email: hswh.project@czgmcn.com

Copyright 2023 ACN Newswire. All rights reserved. http://www.acnnewswire.com

EuroEyes Delivers Solid Results in 2022

HONG KONG, Mar 28, 2023 – (ACN Newswire) – EuroEyes International Eye Clinic Limited ("EuroEyes" or the "Company", together with its subsidiaries, the "Group", stock code: 1846), is a leading brand in the vision correction industry, combining German ophthalmology excellence with 26 years of experience and individualised customer care, principally engaged in the provision of vision correction services in Germany, Denmark, the People's Republic of China ("the PRC") and the United Kingdom. EuroEyes is pleased to announce its annual results for the year ended 31 December 2022 (the "Year").

Key Highlights
— For the year ended 31 December 2022, the Group's total revenue was approximately EUR74.0 million, representing an increase of approximately 7.5% YoY.
— The acquisition of London Vision Clinic Partners Limited, one of the leading brands in the global vision correction industry, has exceeded the revenue and EBIT targets agreed in the acquisition agreement.
— Despite a decrease in profit contribution in HKD terms due to the depreciation of the Euro against the Hong Kong Dollar, the unfavourable currency fluctuation had no material effect on the Group's operations.
— The Group faced many challenges in 2022 due to the global COVID-19 pandemic and its related control policies, but remained confident in its business model and adaptability.

Overcoming a Difficult Business Environment with a Solid Foundation in Lens Surgery
EuroEyes faced a challenging year in 2022 due to the unfavourable macro environment created by the global COVID-19 pandemic and its related control policies, as well as geopolitical turmoil, inflation and currency fluctuations. Despite these challenges, the Group remained confident in its business model and adaptability, with a solid foundation focused on lens surgery, and is gradually getting back on track and outperforming its pre-COVID numbers. Although the depreciation of the Euro against the Hong Kong Dollar resulted in a lower profit contribution in HKD terms and affected the Group's financial position and performance, the unfavourable currency fluctuations did not have a significant operational effect on the Group.

In 2022, the Group's total revenue was approximately EUR74.0 million, representing an increase of approximately 7.5% YoY (HK$ equivalent: 610.3 million). Adjusted gross profit was approximately EUR33.4 million (HK$ equivalent: 275.6 million), representing an adjusted gross profit margin of approximately 45.1%. Net profit after tax was approximately EUR10.1 million (HK$ equivalent: 83.5 million), and after adjustment for non-recurring items, the Group's adjusted net profit after tax was approximately EUR12.3 million (HK$ equivalent: 101.2 million), representing an adjusted net profit margin of approximately 16.6%. The Group's adjusted EBITDA reached over EUR29.4 million (HK$ equivalent: 230.0 million), a testament to its adaptability and resilience.

The Board of Directors has resolved to declare a final dividend of HK0.06266 per share for the year ended 31 December 2022 (2021 final: HK$0.09932 per share).

In terms of geographic regions, revenue from Germany, China, the United Kingdom and Denmark was approximately EUR40.7 million (HK$ equivalent: 335.6 million), EUR11.9 million (HK$98.4 million equivalent), EUR13.5 million (HK$111.2 million equivalent) and EUR7.9 million (HK$65.1 million equivalent), respectively, representing approximately 55.0%, 16.1%, 18.2% and 10.7%, of total revenue, respectively.

In terms of surgery type, lens exchange surgery and phakic lens (ICL) surgery remained an integral and major source of revenue for the Group's business, together accounting for approximately 57.3% (2021: approximately 65.3%) of total surgery revenue for the Year. Revenue from refractive laser surgery grew by 32.8% YoY to approximately EUR29.9 million (HK$ equivalent: 246.4 million), accounting for approximately 41.1% of total revenue, mainly attributable to the first consolidation of London Vision Clinic, which focuses on refractive laser surgery. Meanwhile, revenue from lens exchange surgery, including monofocal and trifocal lens exchange surgeries, dropped 6.6% YoY to approximately EUR32.9 million (HK$ equivalent 271.2 million), accounting for approximately 45.3% of total revenue.

Strategic Acquisition of London Vision Clinic Exceeds Growth Expectations; Continues the Momentum and Outperform in the "New Normal"
Despite continued operational headwinds caused by the pandemic, the Germany business maintained the momentum of the previous year, demonstrating impressive cost control with lower marketing and administrative expenses compared with the previous year.

Elsewhere in Europe, EuroEyes's Denmark clinic was an immediate success and gained market acceptance with the support of its ambassador, European football legend Michael Laudrup. The business gained momentum in the second half of 2022, returning to pre-COVID numbers and recording a strong start to 2023.

Meanwhile, the Group's operations in the United Kingdom performed well ahead of earnings expectations. EuroEyes announced the acquisition of the London Vision Clinic ("LoVC") on 20 January 2022 for a completion consideration of GBP13,130,000. For the first earn-out period in 2022, LoVC exceeded its agreed revenue and EBIT targets as stated in the share purchase agreement under the acquisition, reaching GBP11.2 million and GBP3.2 million, respectively. The Group believes that the acquisition of LVCP will enable it to expand its business by entering London's high-end refractive and presbyopia surgery markets. By implementing PRESBYOND Laser Blended Vision treatment at EuroEyes, the Group is able to treat a larger group of presbyopic patients at an earlier stage.

In the PRC, EuroEyes saw a double-digit decline in revenue and earnings due to nationwide COVID-19 restrictions and multiple lockdowns during the first half of 2022 in major cities where the Group operates. However, after the relaxation of these restrictions in China, the Group's activity rebounded significantly, with a notable pick-up in business after the Chinese New Year in February.

In the "New Normal" business environment in 2023, the Group expects to open three new clinics in Germany, which will elevate EuroEyes to another level in Germany and safeguard its market leader position. The Group is set to open its new flagship Laser Eye Clinic ("LEC") in London in June 2023, in a central, high-traffic location in Knightsbridge. In line with its market expansion strategy, the Group will also open its first flagship clinic on Russell Street in Hong Kong's Causeway Bay in the first half of 2023.

The lifting of the two-year pandemic-related restrictions on inter-country travel across Europe has shifted consumer interest towards leisure travel, which has delayed patients' operation schedules, but demand for procedures in Europe is expected to rebound after the end of the vacation season. As a result, EuroEyes has accelerated the implementation of its mergers and acquisitions strategy, and is focusing on pursuing targets such as well-established, privately owned eye clinics in Europe.

Dr. Jorn Slot Jorgensen, the Founder, Chairman and CEO of EuroEyes said, "2022 presented significant challenges due to the pandemic, but we are immensely proud of the resilience of our business and remain optimistic about our ability to adapt and thrive during the recovery phase. Our commitment to our employees in the PRC is unwavering, and we have maintained full salaries and avoided layoffs, reflecting our values of talent retention and teamwork. In 2023, our strategy is to consolidate our existing clinics and maximise profitability by optimizing capacity utilization rates. As we approach our 30th anniversary, EuroEyes will build on our solid foundation in lens surgery to increase market penetration and expand our global footprint, driving organic growth and reinforcing our position as a leading player in the vision correction industry."

About EuroEyes International Eye Clinic Limited
EuroEyes was established in 1993 and is one of the leading brands in the vision correction industry that combines German ophthalmology excellence and over 25 years of experience with individualised customer care. EuroEyes is one of the few eye clinic groups with a far- reaching geographical coverage, with operations in Germany, Denmark, the PRC and the UK. The Group's vision correction services include (i) refractive laser surgery (which includes ReLEx smile and Femto LASIK); (ii) phakic lens (ICL) surgery; (iii) lens exchange surgery (which includes the monofocal and trifocal lens exchange surgery) and (iv) others (which include PRK/LASEK and ICRS implantation).


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