Essex Bio-Technology Announces 2022 Annual Financial Results

HONG KONG, Mar 8, 2023 – (ACN Newswire) – Essex Bio-Technology Ltd ("Essex" or the "Group", Stock Code: 1061.HK) today announced the annual results for the year ended 31 December 2022.

Financial Performance

During the year under review, the financial results of the Group, have been negatively impacted and ongoing clinical trial programmes have been delayed due to disruptions resulted from sporadic emergence and persistent spread of COVID-19 and the ensuing lockdowns instituted under the "zero-COVID policy" in the PRC. As of the date of the results announcement, the clinical operations of hospitals and outpatient clinics progressively resumed to normalcy.

For the year ended 31 December 2022, the Group achieved a consolidated revenue of approximately HK$1,318 million, with a net profit of approximately HK$225 million. The net profit was weighed down by an impairment loss of approximately HK$ 25.8 million on goodwill arising from the acquisition of YesDok Pte Ltd and its wholly-owned subsidiary in Indonesia.

As of 31 December 2022, the Group had cash and cash equivalents of approximately HK$544 million (2021: approximately HK$671 million). The Board is pleased to propose a final dividend of HK$0.025 (2021: HK$0.055) per ordinary share to be approved at the upcoming annual general meeting of the Group. Together with the interim dividend of HK$ 0.04 per ordinary share paid on 21 September 2022, the total dividend for 2022 would be HK$ 0.065 (2021: HK$ 0.095) per ordinary share.

Revenue of Ophthalmology and Surgical Segments

The Group's revenue is primarily made up of the segments of Ophthalmology and Surgical (wound healing). The revenue of Ophthalmology is approximately HK$554 million, accounted for approximately 42.0% of the Group's revenue, while the revenue of Surgical is approximately HK$764 million, representing approximately 58.0% of the Group's revenue. The core products that are as current growth driver under each segment are:

1. Ophthalmology – Beifushu series (Beifushu eye drops, Beifushu eye gel and Beifushu unit-dose eye drops), Tobramycin Eye Drops, Levofloxacin Eye Drops, Sodium Hyaluronate Eye Drops and Shilishun (Iodized Lecithin Capsules); and

2. Surgical (Wound care and healing) – Beifuji series (Beifuji spray, Beifuji lyophilised powder and Beifuxin gel), Carisolv dental caries removal gel, Dr. YaDian mouth wash and Yi Xue An Granules.

Significant Business Development Activities

The Group is committed to pragmatically investing in new products and technologies to strengthen the Group's product and research and development ("R&D") pipeline as near to mid-term growth driver in ophthalmology and long-term plan for new therapeutics in oncology. During the period under review, significant milestones achieved under business development activities are outlined as follows:

Through acquisition, Shilishun became the company's new added core product

On 8 March 2022, the acquisition of intellectual property rights relating to technologies and process of product R&D, production and right of Marketing Authorisation Holder of Shilishun (Iodized Lecithin Capsules) was completed and Shilishun (Iodized Lecithin Capsules) is being regarded as one of the Group's core products since then.

Secured Exclusive Global Rights and Interests of SkQ1 in the field Ophthalmology from Mitotech

In order to provide the Group with flexibility and independence in the continuing development of the US FDA VISTA programme in the field of dry eye disease and allow the Group to explore further the development of products for other ophthalmic indications to meet the clinical and commercial needs of the Global (as defined below) market, on 13 October 2022, the Group successfully secured (i) a patent assignment deed (the "Patent Assignment Deed"); and (ii) a patent and know-how licence agreement (the "Patent and Know-how Licence Agreement", together with the Patent Assignment Deed, the "Agreements") relating to SkQ1 in the field of ophthalmology from Mitotech.

Pursuant to the Patent Assignment Deed, Mitotech agreed to assign to the Group all the rights of a list of inventions and patents relating to SkQ1 in the field of ophthalmology and all ophthalmic indications.

Pursuant to the Patent and Know-how Licence Agreement, Mitotech agreed to grant the Group an exclusive, transferable and irrevocable Global licence to use a list of patents owned by Mitotech relating to SkQ1 to develop, manufacture, sell and supply any therapeutic products or therapies applied to the eye and its adnexa (the "Products"), including the full global (excluding Armenia, Belarus, Kazakhstan, Kyrgyzstan and Russia) ("Global") right to apply for and obtain patents, to apply for and obtain Global regulatory approval for clinical trials, and to obtain marketing authorisation in relation to the Products.

Following the acquisition of the intellectual property rights relating to SkQ1 on 13 October 2022, the Group's priority is to complete the transfer of chemistry, manufacturing and controls (CMC), know-how and intellectual property rights relating to SkQ1. Concurrently, the Group is re-establishing the VISTA programme with regulators for mitigating any identifiable risks before continuing with the clinical trial. According to Frost & Sullivan, the number of patients with moderate-to-severe dry eye disease alone was around 120 million in the PRC in 2020.
The potential market size of the SkQ1 Product is enormous.

EB12-20145P (HLX04-O) global phase 3 clinical study makes significant progress

In 2020, the Group entered into a co-development and exclusive license agreement with Shanghai Henlius Biotech, Inc. to co-develop a pharmaceutical product EB12-20145P, a recombinant anti-vascular endothelial growth factor ("anti-VEGF") humanized monoclonal antibody injection for the treatment of exudative (wet) age-related macular degeneration ("wet-AMD"). During the period under review, the product has been approved to commence the phase 3 clinical trial in Australia, the United States, Singapore, Russia, Serbia and European Union countries such as Hungary, Spain, Latvia, the Czech Republic and Poland. Also, the first patient has been dosed in the phase 3 clinical study of EB12-20145P for the treatment of wet-AMD in the PRC, Latvia, Australia and the United States.

In February 2023, the Group entered into an amendment agreement with Henlius to amend certain terms of the Co-Development License Agreement, which include payments for regulatory and commercial sales milestones and development costs in respect of the Anti-VEGF Licensed Product, details of which are in the announcement dated 22 February 2023 and the annual results announcement on 8 March 2023.

The Anti-VEGF Licensed Product can be used for treating wet-AMD, diabetic macular edema, macular edema caused by retinal vein occlusion and myopic choroidal neovascularisation. According to Frost & Sullivan, the estimated number of patients of these 4 categories of disease is over 15.8 million in the PRC in 2020. Assuming each patient applies 4 doses in the first year of treatment and 2 to 3 doses in subsequent years, the potential market size of the product is enormous.

Honors and Awards Obtained In 2022

The Group has been included in 2022 Forbes Asia's Best Under A Billion list, a testimony to the Group's achievements to date. Forbes Asia's Best Under A Billion list spotlights 200 top-performing publicly listed small and mid-sized companies in the Asia-Pacific region with annual sales under US$1 billion. In addition, the Group was conferred with China Excellent IR – The Best Shareholder Relationship Award and The Best ESG Award. In addition, Zhuhai Essex Bio-Pharmaceutical Company Limited, a wholly-owned subsidiary of the Group, has been recognised as one of the 2021 top 10 pharmaceutical and health manufacturing companies in Zhuhai, and has also been recognised as one of the 2021 top 100 chemical pharmaceutical companies in the PRC. The Group's Beifushu has been awarded as one of the Chinese reputable medicine brands in four consecutive years. This is a testament to the recognition by the industry for the efficacy and quality of our flagship biologic drug.

Market Development Entrenched Market Access Capability

The Group has been relentlessly investing in establishing and strengthening its market access capability. As of 31 December 2022, the Group maintains a network of 43 regional sales offices in the PRC and a total number of about 1,240 sales and marketing representatives, covering more than 10,900 hospitals and medical providers, coupled with approximately 2,130 pharmaceutical stores, which are widely located in the major cities, provinces and county cities in the PRC. Sales to lower-tier cities is supplemented by on-line platform for medical consultation and e-prescription, the on-line platform is further deployed for serving patients with chronic diseases.

The Group's expansion of its market access into Southeast Asian countries via its base in Singapore has been gaining good development traction since 2020.

Research and Development

During the period under review, the Group remains focused executing its 5-year (2021 to 2025) R&D's development plans. As at the date of the announcement, there are 16 R&D programmes in the pre-clinical to clinical stage, out of which the following 4 ophthalmology programmes (inclusive of a new addition of EB11-21148P in 2022) are in late clinical stage and as mid-term growth drivers:

— EB11-18136P: SkQ1 eye drops, second phase 3 clinical trial (US FDA) (VISTA-2) topline data released on 24 February 2021

— EB11-15120P: Azithromycin eye drops, ongoing review by external experts (National Medical Products Administration ("NMPA") in the PRC)

— EB12-20145P: Bevacizumab for wet age-related macular degeneration ("wet-AMD"), phase 3 clinical trial (US FDA, European Medicines Agency, Therapeutic Goods Administration and NMPA in the PRC)

— EB11-21148P: Cyclosporine eye drops, phase 2 clinical trial (NMPA in the PRC)

The Group holds a total of 69 patent certificates or authorisation letters, which include 50 invention patents, 14 utility model patents and 5 design patents. The Group currently has diversified its R&D resources to multiple research sites in Zhuhai (PRC), Boston (United States), London (United Kingdom) and Singapore which support not only our pursuit of new therapeutics but also our recruitment of global talents.

Mr. Patrick Ngiam, Chairman of Essex, said, "Despite yet another difficult year inflicted by the pandemic of COVID-19 on us all, the tenacity, drive and leadership in our DNA were able to deliver sustained stakeholder value. Barring any unforeseen circumstances, being resilient, relevant and growth ready, the Group is optimistic of delivering progressive results.

I would like to take this opportunity to express my sincere gratitude to all stakeholders, business associates and valued customers for the trust, support and cooperation accorded to us, and each and every member of the Group for their relentless efforts rendered in shaping the Group into being a progressive and promising pharmaceutical player."

Full version of Essex's FY2022 Annual Results Announcement can be downloaded at:
https://www1.hkexnews.hk/listedco/listconews/sehk/2023/0308/2023030800766.pdf

About Essex (1061.HK)

Essex Bio-Technology Limited is a bio-pharmaceutical company that develops, manufactures and commercialises genetically engineered therapeutic b-bFGF (FGF-2), having six commercialised biologics marketed in China since 1998. Additionally, it has a portfolio of commercialised products of preservative-free unit-dose eye drops and Shilishun(Iodized Lecithin Capsules) etc.. The products of the Company are principally prescribed for the treatment of wounds healing and diseases in Ophthalmology and Dermatology, which are marketed and sold through approximately 10,900 hospitals and managed directly by its 43 regional sales offices in China. Leveraging on its in-house R&D platform in growth factor and antibody, the Company maintains a pipeline of projects in various clinical stages, covering a wide range of fields and indications.

Media Enquiry:
Strategic Financial Relations Limited (Website: http://www.sprg.com.hk)
Shelly Cheng +852 2864 4857 shelly.cheng@sprg.com.hk
Yan Li +852 2114 4320 yan.li@sprg.com.hk
June Tuo +852 2864 4848 june.tuo@sprg.com.hk
Angela Shen +852 2864 4870 angela.shen@sprg.com.hk
Media: media@essex.com.cn

Investor Enquiry:
Investor Relations: investors@essex.com.cn


Copyright 2023 ACN Newswire. All rights reserved. http://www.acnnewswire.com

OrbusNeich Announces First Annual Results After Listing, Record Revenue of US$136.8 Million, Adjusted Net Profit Up 25% to US$26.7 Million

HONG KONG, Mar 8, 2023 – (ACN Newswire) – OrbusNeich Medical Group Holdings Limited ("OrbusNeich" or the "Group"; stock code: 6929), a major global medical device manufacturer specializing in interventional devices for percutaneous coronary intervention (PCI) and percutaneous transluminal angioplasty (PTA) procedures, today announced its first annual results after its listing on the Main Board of The Stock Exchange of Hong Kong Limited ("HKEX") on 23 December 2022, reporting growth in both revenue and net profit amidst a weak global economy.

Results Highlights:
— Revenue hit a record high of US$136.8 million, up 17.5% year-on-year
— Gross profit increased 13.9% year-on-year to US$92.5 million, with a gross margin of 67.6%
— Adjusted net profit rose 24.9% year-on-year to US$26.7 million with adjusted net profit margin of 19.5%
— Sales in Japan, the PRC and the U.S. achieved year-on-year growth of 8.8%, 38.1% and 122.6%, respectively
— The Group holds more than 180 granted patents worldwide, with more than 40 approved products and a robust pipeline of around 40 products in development
— Sapphire 3 Coronary Dilatation Catheter obtained official registration approval from China's National Medical Products Administration (NMPA), and the Sapphire Neuro balloon was approved in February 2023 by NMPA
— The aggregate annual production capacity increased to approximately 1.4 million balloon products and 56,000 stent products

For the year ended 31 December 2022 ("FY2022"), the Group continued to achieve sales volume growth, driving revenue to a record high of US$136.8 million, up 17.5% year-on-year, leveraging its established reputation as a leading medical device manufacturer with a sales network spanning more than 70 countries and regions across the globe. As a result, gross profit and adjusted net profit(1) both recorded an increase, by 13.9% to US$92.5 million and by 24.9% to US$26.7 million, respectively, while the gross margin remained at a healthy level of 67.6%. Basic earnings per share were US3.17 cents.

The Group has further strengthened its financial position by raising approximately HK$480.8 million through its listing on HKEX. With cash and bank balances totaling US$229.1 million as of 31 December 2022, the Group has abundant internal resources to fuel its R&D and commercialization progress of its pipeline products as well as to expand its production capacity.

Mr. David Chien, Chairman, Executive Director and Chief Executive Officer of OrbusNeich said, "The year 2022 marked an important milestone in OrbusNeich's history. As the first and only medical device company headquartered in the Hong Kong Science Park listed on the HKEX Main Board, we have now established a clear competitive advantage to capture business opportunities and recruit top-tier talent. In 2022, despite that various challenges in the business environment tested our production, logistics, sales and finance capabilities, we weathered the storm and delivered satisfactory results with our three core capabilities of R&D, operations and commercialization. Ultimately, we achieved growth in both established and high-growth markets, as well as record-high revenue and a significant improvement in net profit."

Leveraging established global sales networks to boost revenue
For established markets, the Group continued to broaden its product portfolio to facilitate further market penetration. Back in September 2021, the Group launched Scoreflex Trio in Japan, which has continued to gain market share since its debut.

For the high growth markets, the Group launched Scoreflex NC, the world's smallest profile scoring balloon product, in the PRC market and US market in 2022. In the PRC in particular, the Group continued to expand its presence through the direct sales force established in 2021. Revenue from the PRC market increased significantly by 38.1% to US$23.6 million. As of 31 December 2022, its distribution network in the PRC market covered over 2,000 hospitals in 30 provinces and municipalities.

Since entering the U.S. market in 2017, the Group has been committed to launching innovative products into the market. Adding to the Jade, Sapphire and Teleport products introduced in previous years, the launch of Scoreflex NC in 2022 was well received by the market, enriching the Group's product portfolio in the U.S. market. This not only led to a 122.6% year-on-year increase in revenues from the U.S. market to $16.6 million for FY2022, but also helped to enhance OrbusNeich's brand recognition in this sophisticated market, consolidating its foundation for future growth there.

Continuous investment in R&D to accelerate the diversification of the product portfolio
For more than two decades, the Group has been empowered by its strong in-house R&D capabilities and accumulated experience in product development. Continuous investment in relevant activities has resulted in a wealth of know-how in product design, material treatment and handling, and manufacturing processes. In FY2022, the Sapphire 3 Coronary Dilatation Catheter obtained official registration approval from the NMPA. In addition, the Sapphire Neuro balloon, the first commercialized product in the Group's neuro-interventional device pipeline, obtained NMPA approval in February 2023. As at 31 December 2022, the Group had more than 180 granted patents in major jurisdictions worldwide, and a total of more than 40 products approved or cleared by the Pharmaceuticals and Medical Devices Agency (PMDA) in Japan, the Food and Drug Administration (FDA) in the U.S., the NMPA or the CE Mark. Leveraging the Group's world-leading technology and proprietary know-how, it also had a robust pipeline of around 40 products in development.

"In addition to our existing PCI and PTA devices, we are adding to our portfolio a range of structural heart interventional products, which are being developed by our joint venture OrbusNeich P+F Company Limited ("ON P&F"), as well as a series of neurovascular interventional products. During 2022, ON PJ&F established an R&D and manufacturing site in Shenzhen, the PRC. The new facility serves as a base for ON P+F to advance its R&D efforts for products in its pipeline, including the Vienna Mitral Valve and the Vienna Pulmonary Valve, as well as to introduce world-class technologies such as TricValve – the CE-approved bicaval transcatheter tricuspid valve implantation system, to the PRC and Asia Pacific region," added Mr Chien.

Expanding production base to satisfy growing demand
In order to provide large-scale and consistently high-quality products to customers around the world, the Group continued to expand its production capacity by optimizing production processes at its production bases in Shenzhen, the PRC and Hoevelaken, the Netherlands. In FY2022, the Group entered into a lease agreement for a manufacturing site in Shenzhen, the PRC with a gross floor area of approximately 1,900 m2. With the relocation of certain production processes to the new manufacturing site, the total annual production capacity has been increased to approximately 1.4 million balloon products and 56,000 stent products.

Seizing opportunities by enhancing core competitiveness
Despite looming geopolitical and economic uncertainties, the demand for medical devices in the global market is steadily growing, given the expanding aging world population, rising living standards and economic growth in developing countries. According to a CIC report, the global market size for PCI devices and PTA devices is expected to grow at a CAGR of 12.1% and 11.1%, respectively, while the global market size for PCI balloons, catheters and accessories is expected to grow at a CAGR of 17.2% from 2021 to 2030.

Mr. Chien concluded, "Looking ahead, we are confident that we can fully capture emerging opportunities from the growing market, despite the complex and volatile macro environment. We will adhere to our development strategy of broadening our product lines, enhancing our R&D capabilities, expanding our distribution network, and striving to realize our vision of becoming a world-leading medical device developer and manufacturer that provides innovative and comprehensive endovascular and structural heart interventional solutions that effectively improve patients' quality of life, while also aiming to generate substantial returns for shareholders."

About OrbusNeich Medical Group Holdings Limited
OrbusNeich is a major global medical device manufacturer specializing in interventional devices for percutaneous coronary intervention (PCI) and percutaneous transluminal angioplasty (PTA) procedures. Headquartered in Hong Kong, China, OrbusNeich sells its products in more than 70 countries and regions worldwide. It is also the only PCI balloon manufacturer headquartered in China that ranked among the top six players in all major overseas PCI balloon markets including Japan (No. 2), Europe (No. 4), and the U.S. (No. 6) in terms of PCI balloon sales volume in 2021, according to a CIC report. In addition, it ranked No. 3 in Japan and No. 4 in the U.S. in terms of PTA balloon sales volume in 2021. It also specializes in coronary stent products and is actively expanding into neuro vascular intervention and structural heart disease. As of December 2022, OrbusNeich has more than 180 granted patents worldwide. Its in-house R&D team has more than two decades of product development experience and has developed world-leading proprietary technologies.

For more information, please visit the Group's official website: https://orbusneich.com/

(1). Excluding non-cash and one-off items including unwinding of interests on convertible redeemable preferred shares, share-based compensation expenses, fair value losses of convertible redeemable preferred shares, loss on derecognition of financial liability in relation to convertible redeemable preferred shares and listing expenses.


Copyright 2023 ACN Newswire. All rights reserved. http://www.acnnewswire.com

With U.S. Health Systems Under Growing Pressure to Fill Staff Vacancies, CGFNS Alliance Releases Updated Standards for Ethical Recruitment of Foreign Health Workers

Philadelphia, PA, Mar 7, 2023 – (ACN Newswire) – As U.S. healthcare employers confront major staffing challenges, the Alliance for Ethical International Recruitment Practices, a division of CGFNS International, Inc. (CGFNS), has updated and strengthened its ethical recruitment code, which establishes best practice standards for fair and transparent recruitment of foreign-educated health professionals into the U.S.



The fourth edition of the Health Care Code for Ethical International Recruitment and Employment Practices, known as the "Alliance Code," strengthens recommendations around contract transparency and orientation programs. The Alliance Code was developed by a multistakeholder group representing interests across the sector, including employers, unions, recruiters, and representative nurse organizations.

It comes at a time when a growing global health worker shortage has left health systems struggling to fill vacancies and considering a variety of options, including sometimes turning to recruiting trained professionals from abroad. In the past five years, CGFNS has seen a doubling of its applications from foreign-trained health workers who are seeking eligibility to work in the U.S.

This trend has raised further concerns about ensuring that international recruitment practices are ethical, that they protect the rights of migrating health workers while establishing their obligations, and that recruiting agencies and employers are held accountable in the process. First published in 2008, the Alliance Code is reviewed and updated every five years to adapt to changes in the recruitment landscape and ensure its provisions continue to address basic rights and responsibilities of both migrating health professionals and those who recruit them to work in the U.S. The Code provides guidelines for recruitment agencies and employers, addressing migrant rights including the right to receive a fair contract, to provide informed consent and to access justice.

The Code has been voluntarily adopted by 12 firms that collectively recruit thousands of employees each year and that have undergone the Alliance's rigorous certification process, including a contract review and health professional survey. A list of recruitment firms that have been certified as in compliance with the Alliance Code can be found here. https://www.cgfnsalliance.org/certification_process/view-certified-recruiters/

The 2023 Alliance Code is being released after a year of internal and external review by the Alliance's Board of Governors.

"With the recent pandemic having further driven the growth in global demand for nurses and other health workers, there is increasing concern about ensuring that international recruitment processes are ethical and sustainable," said Alliance Director, Mukul Bakhshi, JD. "This updated 2023 Code reflects recent changes in the recruiting landscape, and we hope it will help push the industry forward in ensuring that recruitment practices are fair and respect basic rights."

"Our organization has been engaged in the work of the Alliance since its inception and fully endorses the Alliance Code," said AONL Chief Executive Officer, Robyn Begley, DNP, RN, NEA-BC, FAAN, Chief Executive Officer of the American Organization for Nursing Leadership (AONL). "A fair and equitable process of recruiting foreign-educated nurses is foundational to achieving a professional practice environment for all nurses. We remain committed to the advancement of high standards of treatment for all staff."

"As the global leader in international credentials evaluation to support health worker mobility, at CGFNS we know that health worker migration into the U.S. brings individuals with critical skills to provide life-saving care. With the shortage persisting and employers stepping up their recruitment of foreign-trained nurses and other health workers, we must all work together to provide better protections to prevent exploitation," said CGFNS President and Chief Executive Officer, Peter Preziosi, PhD, RN, CAE. "We are proud of our work through the Alliance to continue to do our part to support nurses coming into the U.S."

About CGFNS International, Inc.

Founded in 1977 and based in Philadelphia, CGFNS International is an immigration-neutral not-for-profit organization, proudly serving as the world's largest credentials evaluation organization for the nursing and allied health professions. For more information, visit www.cgfns.org.

About The Alliance for Ethical International Recruitment Practices

Since 2008, the Alliance has fostered compliance to standards that advocate responsible, ethical, and transparent recruitment practices in the health care sector. The Alliance monitors certified recruitment organizations and verifies their processes to ensure that these standards are upheld and provides foreign-educated professionals resources to make informed decisions. The Alliance became a division of CGFNS International, Inc., in September 2014. For more information, visit www.cgfnsalliance.org.

Contact Information:
Mukul Bakhshi, Esq.
Chief of Strategy and Government Affairs
mbakhshi@cgfns.org
(215) 243-5825

SOURCE: CGFNS International

Copyright 2023 ACN Newswire. All rights reserved. http://www.acnnewswire.com

EC Healthcare Opened the First Organic Flagship Veterinary Hospital in Hong Kong

HONG KONG, Mar 6, 2023 – (ACN Newswire) – EC Healthcare (the "Company", which together with its subsidiaries is referred to as the "Group", SEHK stock code: 2138), the largest non-hospital medical group in Hong Kong*, is pleased to announce that the Group opened its first organic flagship veterinary hospital, Animal Medical Academy Hospital (AMAH).


From left to right: Dr. Guo Shanshan, Co-Principal of AMAH, Ms Sisy Lao, Director of AMAH, Dr. Phillip Mak, Co-Principal of AMAH, Mr. Levin Lee, Executive Director and Chief Financial Officer of EC Healthcare, Dr. Julie Chow, Chief Proposition Officer (Healthcare) of EC Healthcare, Dr. Tiffany Ho, Department Head of Primary Care of AMAH


Animal Medical Academy Hospital (AMAH) is located in Harbour Crystal Center in Tsim Sha Tsui East, with two floors and a total gross floor area of more than 26,000 sq ft. The hospital is equipped with an internal elevator to connect the ground floor and basement, with separate waiting areas for dogs and cats. The hospital provides veterinary general practitioner services and precious specialty services covering anesthesia & analgesia, neurology and cardiology services. The hospital also provides advanced imaging services equipped with MRI, CT and Cardiac Ultrasound, bundling with an oxygen generating system. The hospital has 10 consultation rooms, 8 pre-surgical induction & recovery monitoring rooms, 14 chemotherapy wards, 18 Intensive Care Units (ICU), 59 wards and internal. The service scope and professional standard all achieved industry-leading level.

Mr. Levin Lee, Executive Director and CFO of EC Healthcare said, "Since entering the veterinary business in 2021, EC Healthcare has been actively consolidating the market, and establish a leading brand. Through corporatization, the Group was able to empower the traditional veterinary business, improving its operational efficiency and boosting its growth. The Group is very honored to partner with Dr. Phillip Mak, a leading expert in the veterinary industry, to jointly establish this hospital. Looking ahead, we look forward to collaborating with more veterinary talents to continuously expand the service scope, paving way for AMAH to become the leading flagship veterinary hospital in Hong Kong. The Group will continue to invest in expanding its veterinary business in Hong Kong, building a renowned brand, and shaping the veterinary business to become a new growth engine for the Group."

About EC Healthcare
EC Healthcare is Hong Kong's largest non-hospital medical service provider*, leveraging its core businesses of preventive and precision medicine, and committed to developing medical artificial intelligence by integrating its multi-disciplinary medical services. The move, which is supported by the Group's high-end branding and quality customer services, is aimed at offering customers safe and effective healthcare and medical services with professionalism. The Group is a constituent stock of the Hang Seng Composite Index and the MSCI Hong Kong Small Cap Index.

The Group principally engages in the provision of one-stop medical and health care services in Greater China. The Group provides a full range of services and products under its well-known brands, including those of its one-stop aesthetic medical solutions provider DR REBORN which has ranked first in Hong Kong by sales for years, a professional hair care center HAIR FOREST, primary care clinics jointly established with health management centre re:HEALTH, a vaccine centre Hong Kong Professional Vaccine HKPV, General outpatient clinic Tencent Doctorwork, the largest one-stop pain management centre in Hong Kong New York Medical Group, the comprehensive dental centres Bayley & Jackson Dental Surgeons, EC DENTAL CARE and Health and Care Dental Clinic, an advanced diagnostic and imaging centre HKAI, an oncology treatment centre reVIVE, a day procedure centre HKMED, a specialty clinic PREMIER MEDICAL CENTRE, SPECIALISTS CENTRAL and NEW MEDICAL CENTER, a paediatric centre PRIME CARE, a gynaecology specialist ZENITH MEDICAL CENTER AND PRENATAL DIAGNOSIS CENTRE, PathLab Medical Laboratories, Ophthalmology Center EC Eye and EC Veterinary Hospital and Imaging Center.

*According to independent research conducted by Frost and Sullivan in terms of revenue in 2020 and 2021


Copyright 2023 ACN Newswire. All rights reserved. http://www.acnnewswire.com

Prenetics Announces Formation of Scientific Advisory Board to Support New Business Strategy in Precision Oncology

LONDON AND HONG KONG, Mar 4, 2023 – (ACN Newswire) – Prenetics Global Limited (NASDAQ: PRE), a leader in genomic and diagnostic testing, is proud to announce the formation of a new Prenetics Scientific Advisory Board (the 'SAB') to provide strategic input based on their scientific knowledge and clinical expertise to help guide the further development of Prenetics' diagnostic cancer genomics platform.



Prenetics has been at the forefront of genomic and diagnostic testing, providing a wide range of genetic testing services to individuals and healthcare professionals around the world. The SAB includes a diverse group of highly respected experts in oncology and genomics, each with unique expertise and backgrounds in the field of precision oncology. Members of the board include Prof. Tony Mok, Prof. Pasi Janne, Prof. Pan-Chyr Yang, Dr. Hua-Chien Chen, Dr. Frank Ong, and Dr. Lawrence Tzang.

"We are honoured to have these accomplished scientific thought-leaders join Prenetics' SAB," said Danny Yeung, CEO and Co-Founder of Prenetics. "Their insights and experience will be an invaluable asset to fuel our innovative solutions in the field of precision oncology. We are particularly excited in the area of early detection for cancer and will share more details in the coming months."

"We are thrilled to have Prof. Mok chair our SAB," Mr. Yeung continued, "Prof. Mok's passion for innovation make him a great fit for Prenetics and look forward to working together to transform the way cancer is identified and treated. Prof. Mok's research has already guided the development of breakthroughs for lung cancer treatment and he has been recognized globally for his impact on the field of precision oncology."

Prof. Mok added "I am delighted to be joining Prenetics and to have the opportunity to work with such a dynamic and innovative team. Precision oncology is a rapidly evolving field, and I believe that Prenetics is well-positioned to make a significant impact in this area. I look forward to contributing my expertise to this important work."

Prenetics' SAB appointees include:

Prof. Tony S. K. Mok

Prof. Mok will lead the SAB and currently serves as Chairman of the Department of Clinical Oncology of Chinese University of Hong Kong, is a non-executive director of AstraZeneca plc (LON:AZN), and an independent director of HUTCHMED (China) Limited (Nasdaq/AIM: HCM; HKEX: 0013). His main research interest focuses on biomarker and molecular targeted therapy in lung cancer.

Prof. Mok was the Principal Investigator and first author on the landmark IRESSA Pan-Asia Study (IPASS), which was the first study that confirmed the application of precision medicine for advanced lung cancer. He has also led and co-led multiple studies including the FASTACT 2, IMPRESS, ARCHER 1050, ALEX and AURA 3. These projects address various aspects on management of EGFR mutation positive lung cancer, and have played a significant role in defining current practice. Prof. Mok has also engaged in clinical research on ALK positive lung cancer and immunotherapy. The series of clinical trials, led or co-led by Professor Mok, have defined precision medicine. His work has been adopted by multiple international guidelines including NCCN, AMP/IASLC/CAP, ASCO and ESMO.

Prof. Pasi A. Janne, MD, PhD

Prof. Pasi Janne is a globally renowned translational thoracic medical oncologist at the Dana Farber Cancer Institute and Professor of Medicine at Harvard Medical School. He is also the Director of the Lowe Center for Thoracic Oncology and the Director of the Belfer Center for Applied Cancer Science. Prof. Janne's research combines laboratory-based study with translational research in clinical trial of novel therapeutic agents in patients with lung cancer. He has made seminal therapeutic discovery including co-discovery of EGFR mutations and has led the development of therapeutic strategies for patients with EGFR mutant lung cancer.

Prof. Pasi Janne's translational research work also led to the successful development of HER3-ADC in NSCLC and combination with Osimertinib to further enhance the potential efficacy of HER3-ADC. Prof. Janne has received multiple awards for his work including from the AACR, ESMO and ASCO.

Prof. Pan-Chyr Yang, PhD

Prof. Yang is the former President of Taiwan University and has been a professor in the department of internal medicine at the College of Medicine for 27 years. He has also served as the Director of the Advisory Office for the Ministry of Education and as Dean for the College of Medicine at Taiwan University. Dr. Yang was honoured with the Joseph W. Cullen Prevention/Early Detection Award at the International Association for the Study of Lung Cancer (IASLC) 2020 World Conference on Lung Cancer.

Prof. Yang is a pioneer and leader in pulmonary ultrasound diagnostics and therapeutics that have revolutionized the management of pulmonary diseases which include lung cancer. He has led a research group to develop the method for detection and quantification circulating cancer cells in peripheral blood and to better predict the prognosis and response to treatment for lung cancer patients. His has led a research group to discover novel genes and pathways that associated with lung cancer pathogenesis and progression. They identified specific gene expression and microRNA signatures that can assist to predict the treatment outcome and may be beneficial for personalized therapy of lung cancer patients.

Dr. Hua-Chien Chen, PhD

Dr. Hua Chien Chen is the Co-founder and the Chief Scientific Officer of ACT Genomics. He has more than 20 years of experience in cancer biology, genomics and drug discovery. Dr. Hua Chien Chen earned his PhD in Biochemistry from National Yang-Ming University in Taiwan and completed his postdoctoral training in Molecular Biology at Case Western Reserve University in the USA.

In 1998, Dr Hua Chien Chen was an Assistant Investigator at the National Health Research Institute, where he worked on the discovery and development of molecular targets for new drugs. Dr. Chen then joined TaiGen Biotechnology as the Biology Director, where he oversaw the drug screening program. From 2006 to 2014, Dr. Chen took up a position as Associate Professor at Chang Gung University, where he established a multiplexed micro-RNA quantification platform for the Molecular Medicine Research Center. This platform was developed to identify non-invasive biomarkers for cancer and other diseases. Dr. Hua Chien Chen has extensive experience in the biotech industry, technology-based project evaluation and license negotiation. Dr. Chen is also an accomplished scientist and acknowledged expert in the fields of molecular biology, oncology and genomics.

Dr. Frank S. Ong, MD

Dr. Frank Ong, MD. Chief Medical Officer for Prenetics and Interim CEO for ACT Genomics is a seasoned industry-leading physician-scientist in Clinical Development (Certified Principal Investigator, Certified Clinical Research Professional, Medical Monitor) and Medical Affairs with clinical fellowship specialization in medical genetics and sub-specialization in clinical molecular genomics laboratory testing for hereditary oncology, common and rare hereditary adult and pediatric conditions, pharmacogenetics, carrier screening, and women's health. Prior to joining Prenetics as Group Chief Medical Officer, Dr. Ong was the Chief Medical Officer and Chief Scientific Officer of Everly Health and held previous leadership roles in Guardant Health (NASDAQ:GH), Illumina (NASDAQ: ILMN) and Roche (SWX: ROG). Dr. Ong led the first FDA 510(k) cleared NGS-based assay and NGS platform in 2013 as well as the first at-home COVID test to obtain Emergency Use Authorization by the US FDA in 2020.

Dr. Ong received his Medical Doctorate at the Keck School of Medicine of the University of Southern California in 2002, and completed his residency and fellowship at the University of California, Los Angeles and Cedars-Sinai Medical Center before serving on the faculty at Cedars-Sinai Medical Center.

Dr. Lawrence T.C. Tzang, Ph

Dr. Lawrence Tzang is the Co-Founder of Prenetics and has served as its Chief Scientific Officer and director since its founding in 2014. He has more than 20 years of experience in molecular diagnostics, genomics as well as laboratory automation. Dr. Tzang has been a registered Medical Laboratory Technologist I at the Board of Medical Laboratory Technologist since 2013, a founding member and ex-secretary at the Hong Kong Society for Behavioral and Neural Genetics in 2011-2022 and a fellow of the Hong Kong Society for Molecular Diagnostic Sciences since 2008. Dr. Tzang received his Ph.D. in Molecular Biology in 2003 and post-doctoral research fellowship at Department of Biology & Chemistry of the City University of Hong Kong from 2003 to 2009.

Dr. Tzang used microarray technologies on gene expression profiling for cancer researches, including vimentin and clusterin gene expression in hepatocellular carcinoma metastasis and key role of a protein in hepatocarcinogenesis, as well as drug resistance in cervical carcinoma. Dr. Tzang has also developed a biochip based genotyping platform for human papillomavirus genotyping and prevalence analysis in cervical cancer. In addition, he also participated in deep proteome profiling of sera from never-smoked lung cancer patients.

About Prenetics

Prenetics is a leading genomics and precision oncology company dedicated to transforming patient care through advanced genomic and molecular technologies. Our new business focus is on precision oncology, specifically on early detection and treatment. We recently acquired ACT Genomics, the only Asia-based company to receive FDA clearance for a comprehensive genomics profiling test for solid tumors. ACT has also enabled us to expand our capabilities and offer comprehensive cancer solutions to patients worldwide. Our team of world-class scientists, healthcare experts, and technology innovators are committed to driving forward precision oncology to improve patient outcomes. At Prenetics, we believe that every patient deserves personalized, effective, and affordable cancer care, and we are dedicated to making that a reality. Prenetics is listed on NASDAQ with the ticker PRE. To learn more about Prenetics, visit www.prenetics.com

About ACT Genomics

ACT Genomics is an innovation-driven cancer solution provider with offices in Taipei, Hong Kong, Singapore, Tokyo, Bangkok and the United Kingdom. With its Next-Generation Sequencing (NGS) technology, CAP-accredited laboratories, experienced bioinformatics team, and proprietary AI algorithms, ACT Genomics provides optimal cancer treatment planning, immunotherapy evaluation, cancer relapse and drug resistance monitoring, as well as cancer risk assessment services to medical professionals. Its motto is "Turn Genomics into Action". ACT Genomics is a group company of NASDAQ-listed Prenetics. To learn more about ACT Genomics, visit www.actgenomics.com.

Investor Relations Contact:
Email: investors@prenetics.com

ICR Westwicke:
Caroline Corner +1 415 202 5678 Email: caroline.corner@westwicke.com

Forward-Looking Statements
In addition to historical information, this release contains "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995. In some cases, you can identify forward-looking statements by terminology such as "believe," "may," "will," "estimate," "continue," "anticipate," "intend," "should," "plan," "expect," "predict," "potential," or the negative of these terms or other similar expressions. These statements are based on estimates and forecasts and reflect the views, assumptions, expectations, and opinions of Prenetics and ACT Genomics. Any such estimates and assumptions, expectations, forecasts, views or opinions, whether or not identified in this press release, should be regarded as indicative, preliminary and for illustrative purposes only and should not be relied upon as being necessarily indicative of future results. These statements include, but are not limited to, statements by our management or the board regarding plans, objectives, strategic direction of Prenetics and ACT. Our expectations and beliefs regarding these matters may not materialize, and actual results in future periods are subject to risks and uncertainties that could cause actual results to differ materially from those projected. Because of these uncertainties, you should not make any investment decisions based on our estimates or forward-looking statements. All information provided in this press release is as of the date of this press release. Prenetics does not undertake any obligation to update any forward-looking statement, whether as a result of new information, future developments, or otherwise, except as required under applicable law.


Copyright 2023 ACN Newswire. All rights reserved. http://www.acnnewswire.com

CATALIST-listed AOXIN Q&M reports lower revenue of RMB 140m for full year ended 31 December 2022

SINGAPORE, Mar 3, 2023 – (ACN Newswire) – Catalist listed Aoxin Q&M Dental Limited, announced on 1 March 2023, a 12.8% lower revenue of RMB139.7 million for full year ended 31 December 2022 (FY2022). The Group reported a net loss after tax excluding impairment loss on investment in our associate of RMB7.3 million for FY2022, primarily due to the number of shutdowns from China's zero-Covid policy that was in place all the way up until 8 January 2023.




Dr. Shao Yongxin, Executive Director and Group Chief Executive Officer of Aoxin Q&M said, "Companies in China have had to face head-on, the challenges brought about by the COVID-19 pandemic and Aoxin is no exception. While we have recorded net loss after tax excluding impairment loss on investment in our associate of RMB7.3 million for FY2022, we are optimistic about the company's prospects for 2023 now that China has moved from its zero-Covid stance to a "living with Covid" one. Aoxin's primary healthcare sector has been resilient and we are well-positioned and prepared to ride the wave as the economy recovers in step with the entire country opening up."

In addition, "Indeed, 2022 will go down as one of the most challenging years in recent history for companies operating in China, as cities and entire provinces were closed and sealed with little to no advance warning for days and sometimes weeks. Aoxin was certainly not spared and in fact, the number of days of shutdown for the Group's hospitals and polyclinics amounted to some 844 business days in total. This includes days when some clinics could not operate because a substantial number of dentists and nurses were down with Covid themselves. Throughout this time, we have been extremely prudent in maintaining cost discipline, reducing some of our liabilities and look forward to strongly ride on the recovery in the coming year."

Revenue

The Group's revenue was lower by RMB20.5 million or 12.8% from RMB160.2 million for the financial year ended 31 December 2021 (FY2021) to RMB139.7 million for the financial year ended 31 December 2022 (FY2022). The lower revenue was largely due to the resurgence of Covid-19 in Liaoning Province, PRC in the second and fourth quarters of 2022 which affected all business segments of the Group.

Revenue from primary healthcare segment was lower by 7.3% from RMB93.9 million in FY2021 to RMB87.0 million in FY2022. This decrease was largely due to the temporary closure of our hospitals as instructed by the local authorities, and a decrease in number of patients visiting dental polyclinics due to dental services being classified as a non-essential service.

Revenue from distribution of dental equipment and supplies segment was lower by 22.0% or RMB11.1 million from RMB50.4 million in FY2021 to RMB39.3 million in FY2022. The lower revenue was largely due to lower demand for dental equipment from government hospitals due to lesser government tenders obtained in the six months ended 30 June 2022, partially offset by a slight increase in demand as a result of contracts secured during the six months ended 31 December 2022 (2H2022). The supply of dental equipment was also impacted by supply chain disruption as a result of Covid-19.

Revenue from laboratory services segment decreased by 15.5% from RMB15.9 million in FY2021 to RMB13.4 million in FY2022 due to decrease in demand from government dental hospitals largely due to the temporary closures.

Other income and gains were lower by 8.3% or RMB0.2 million from RMB2.9 million in FY2021 to RMB2.7 million in FY2022 mainly due to lower profit guarantees from vendors of acquired subsidiaries. However, the lower income and gains were partially offset by the higher government grant and rental discount.

Net Loss (Excluding one off impairment loss on investment in associate)

The Group's net loss remained at RMB7.3 million for FY2022 and FY2021. The net loss of RMB7.3 million for FY2022 included tax credit of RMB5.1 million and partially offset by increase in operation loss which was largely attributable to (i) reduction in revenue by RMB20.5 million, (ii) higher % of staff costs to revenue due to regulatory increase of social insurance contributions resulting in an increase of the contribution rate, and (iii) higher unrealised foreign exchange loss arising from the translation of Singapore Dollars denominated balances to Renminbi.

Dr. Shao Yongxin added, "Our long-term growth trajectory remains intact and we will work hard to execute the strategic plans for the Group, as well as increase the revenue of our hospitals and clinics by maximising our cost efficiency of our operations."

Dr. Ong Siew Hwa, Chief Executive Officer & Chief Scientist of Acumen and Executive Director of Aoxin Q&M added, "Acumen Diagnostics Pte Ltd ("Acumen"), will continue to progressively roll out its pipeline of new non-Covid PCR Tests. These includes the test for sepsis, identification of bacteria pathogens and their associated antimicrobial resistance in hospitalised pneumonia, as well as colorectal cancer screening and pharmacogenomics. Our colorectal cancer screening is already offered by medical practitioners to patients.

In addition, Acumen had been awarded the tender for the operation of a Joint Testing and Vaccination Centre by the Singapore Ministry of Health. The award is for a period of 15-month and expected to contribute at least S$3.6 million to Acumen's revenue during the contract period."

Looking Forward

Aoxin's FY2022 results reflects the significant impact of the Covid lockdowns in China to the Group's overall revenue. With the opening up of the entire country, the business climate and overall economy in the PRC is expected to turn positive and we thus look forward to the Group's revenue to correspondingly improve substantially.

Building on its strong fundamentals and strength, our Group's homegrown medical associate company, Acumen will ramp up on the implementation of its portfolio of non-Covid PCR tests in 2023.

The Group will continue to focus on disciplined management of operating expenditures, costs and capital expenditures. The Group will continue to closely monitor its expenses and maximise cost efficiency for all its operations. In addition, the Group is considering a potential fund raising exercise within the next 12 months.

Barring any unforeseen circumstances in the year ahead, we expect operations to gradually improve in 2023 as China opens up and the economy recovers. We do not foresee at this point in time, any known factors or events that may adversely affect the Group in the next 12 months.

This media release is to be read in conjunction with the Group's announcement posted on SGXNET on 1 March 2023.
See https://links.sgx.com/1.0.0/corporate-announcements/SFUGJHC6YKNDTSVE/ce5b8462fc6d4eecd12bf30dac451fa755d625f08f9518e56256861b61b113f3

This announcement has been reviewed by the Company's sponsor, PrimePartners Corporate Finance Pte. Ltd. (the "Sponsor"). It has not been examined or approved by the Singapore Exchange Securities Trading Limited (the "Exchange") and the Exchange assumes no responsibility for the contents of this document, including the correctness of any of the statements or opinions made or reports contained in this document.

The contact person for the Sponsor is Ms. Lim Hui Ling, 16 Collyer Quay, #10-00 Collyer Quay Centre, Singapore 049318, sponsorship@ppcf.com.sg

About Aoxin Q&M Dental Group Limited (Stock Code: 1D4.SI) www.aoxinqm.com.sg

Aoxin Q&M Dental Group Limited ("Aoxin Q&M" or together with its subsidiaries, the "Group") is a leading provider of private dental services in the Liaoning Province, Northern People's Republic of China ("PRC"). The Group operates 16 dental centres, comprising 10 dental polyclinics and 6 dental hospitals, located across 8 cities in Liaoning Province, namely Shenyang, Huludao, Panjin, Gaizhou, Zhuanghe, Jinzhou, Dalian and Anshan.

A majority of the dental centres are accredited as Designated Medical Institutions of Medical Insurance. Additionally, the Group is engaged in the provision of dental laboratory services, as well as the distribution and sale of dental equipment and supplies in the Liaoning, Heilongjiang and Jilin Provinces in Northern PRC.

Aoxin Q&M was listed on the Catalist board of the Singapore Exchange Securities Trading Limited on 26 April 2017.

Media and Analysts please contact the below for more information:
Waterbrooks Consultants Pte. Ltd.
+65 6958 8008, query@waterbrooks.com.sg
Wayne Koo (M): +65 9338 8166, wayne.koo@waterbrooks.com.sg
Derek Yeo (M): +65 9791 4707, derek@waterbrooks.com.sg

Copyright 2023 ACN Newswire. All rights reserved. http://www.acnnewswire.com

Q&M reports lower full year profits due to impairments and decrease in Covid-19 related revenue

SINGAPORE, Mar 2, 2023 – (ACN Newswire) – Mainboard-listed Q&M Dental Group (Singapore) Limited today reported total revenue of S$181.2 million, and profit after tax attributable to parent (PATMI) of S$11.3 million for the twelve months ended 31 December 2022 (FY2022). The Group Earnings before interest, tax, depreciation, amortisation (EBITDA) for FY2022 was S$35.2 million.





For FY2022, Core Healthcare revenue increased 2% to S$172.1 million and Core Healthcare EBITDA increased by 6% to S$39.5 million.

For the Other Business segment, revenue contributions from the Group's medical laboratory business dropped very significantly with demand for COVID-19 testing now reduced to a very small group, following the government eliminating all tests for locals and foreign visitors to Singapore.

As at 31 December 2022, the Group's financial position remains strong with Net Assets of S$96.5 million, as well as cash and cash equivalents of S$39.7 million. Bank borrowings plus finance leases amounted to S$85.1 million.

The Group declares a second interim dividend of 0.6 Singapore cent per ordinary share for 4Q2022. Together with the 0.4 Singapore cent dividend paid out for 1Q2022, the total dividends for FY2022 work out to 1.0 Singapore cent. The 4Q2022 dividend will be paid on 24 March 2023.

Q&M Chief Executive Officer Dr Ng Chin Siau said, "We are pleased to note that our Core Healthcare Business has continued to demonstrate strong resilience and is well-positioned to grow in the coming year.

We are heartened by the fact that the Core Healthcare's Revenue and EBITDA compound annual growth rate (CAGR) for the last 5 years (FY2018 to FY2022) are 9% and 26% respectively. We believe that with the strategies that we are implementing, this will continue to be the case.

The Group had been very nimble in the Covid-19 period, treating and reacting to threats as opportunities with resulting outstanding results. As we transition to a "living with COVID-19" stance now, long term growth will be driven by improved utilisation of our professional staff, optimising the use of clinics and improving margins. The key to this approach is continuing training and upgrading of our dentists and professional assistants and use of technologies. The Group is very well placed to implement these strategies with the Q&M College of Dentistry, our investments in technologies and an experienced management team, which has led the exponential expansion of our core businesses. "

Dr Ng continued, "We see the future of dentistry lying in combining the dentist's domain expertise and valuable experience with data-centric analysis to generate objective and highly accurate dental healthcare plans that are specifically tailored to individual needs.

With the above in mind, we will continue to prioritise in investing in our people as they are the bedrock upon which our long term success lies. Whether frontline or behind the scenes, they play a vital role in ensuring that we deliver the best dental healthcare to our patients, every single day."

4Q2022 Core Business Healthcare- Financial Performance

Revenue from Core Healthcare Business continues to inch up to S$46.2 million for the three months ended 31 December 2022 (4Q2022) mainly due to the organic growth of dental clinics (See Table 1). The Group added a net 10 dental clinics in Singapore and net 6 dental clinics in Malaysia the last 12 months.

Over the last 4 consecutive quarters ie 4Q2022 vs 1Q2022, 2Q2022 and 3Q2022, Core Healthcare Business grew between 9% and 12%. (See Table 2 above)

Operational Update and Recent Developments

The Group currently operates a total of 152 dental clinics, of which 107 are located in Singapore, 44 in Malaysia and 1 in PRC China. (See Table 3 above)

1. Dental Operations (Singapore and Malaysia)

The Group is initiating a strategy of intensive organic growth of dental clinics and will expand its team of dentists to support the future growth of its operations in Singapore. We will continue to develop, invest and optimise our digital guided clinical decision support system to provide the most effective and suitable treatment plans for our patients.

With rising standards of living and higher expectations of dental healthcare in Singapore, the Group believes it is well-positioned to meet the rising demand for primary and high-value specialist dental healthcare services for its patients.

In Malaysia, the Group operates 44 clinics with 16 dental clinics in Johor, 9 in Kuala Lumpur, 12 in Selangor, 4 in Melaka and 3 in Negeri Sembilan. The eventual number of dental outlets will depend on available opportunities and pertinent market conditions. The increasingly tight labour market is a limiting factor.

2. Dental Operations (People's Republic of China (PRC))

The main thrust of the Group's proposed expansion in PRC is through organic growth to develop a new and sustainable growth pillar that can yield long term value for the Group.

The Group is also actively exploring opportunities to expand its dental business to Southeast Asian countries at this time.

Strengthening Capabilities, Fortifying Relationships, Building Futures

Q&M has firmly committed to keep the business on a steady growth path that is always forward looking, sustainable yet firmly anchored in the Company's philosophy.

1. Expansion of network of dental clinics in Singapore, Malaysia and Southeast Asia and China

The Group is continuously looking for opportunities to expand its dental business to Southeast Asian countries with an emphasis on utilisation and optimisation of existing clinics, and only opening new clinics where appropriate and meets the overall strategic objectives of the Company.

2. Medical Laboratory

The Group's medical laboratory will continue to progressively roll out its pipeline of new PCR tests for various purposes. These include the tests for sepsis, identification of bacteria pathogens and their associated antimicrobial resistance in hospitalised pneumonia, as well as colorectal cancer screening and pharmacogenomics.

Looking Forward

Barring any unforeseen circumstances, there are no known significant changes in the trends and competitive conditions of the industry in which the Group operates and no other major known factors or events that may adversely affect the Group in the next reporting period and the next 12 months. However, the Group and the industry is impacted by increased manpower and occupancy costs, as well as shortage of and competition for trained nurses.

[1] Core Healthcare Business excludes contributions from the Group's medical laboratory, share of profit from disposal of associate, Aidite, other gains, other losses and expenses incurred on the development of the Group's digital Artificial Intelligence (AI) guided clinical decision support system as well as rental rebates received from the Singapore Government.

Please see links for PDF documents from SGXNET.
Financial Results: https://links.sgx.com/FileOpen/QnM_4Q_2022_Announcement.ashx?App=Announcement&FileID=748726
Press Release: https://links.sgx.com/FileOpen/QnM_PR_FY2022.ashx?App=Announcement&FileID=748727

About Q&M Dental Group (Singapore) Limited (QC7.SI)

Q&M Dental Group (Singapore) Limited (QC7.SI) ("Q&M" or together with its subsidiaries, the "Group") is a leading private dental healthcare group in Asia.

The Group owns the largest network of private dental outlets in Singapore, operating 107 dental outlets across the country. Underpinned by about 270 experienced dentists and over 350 supporting staff, the Group sees an average of 40,000 patient visits a month in Singapore. The Group also operates 5 medical clinics and a dental supplies and equipment distribution company.

Outside of Singapore, the Group has 44 dental clinics and a dental supplies and equipment distribution company in Malaysia, as well as a dental clinic in the People's Republic of China (PRC). Q&M is also the substantial shareholder of Aoxin Q&M Dental Group Limited, a dental Group listed on the Catalist board of the Singapore Exchange that operates dental clinics and hospitals primarily in the north-eastern region of the PRC. The Group aims to expand its operations geographically and vertically through the value chain in Malaysia, the PRC and within the ASEAN region.

The Q&M College of Dentistry was established in 2019 to offer postgraduate dental education as part of its commitment to continual education and professional development of dentists. It offers Singapore's first private postgraduate diploma programme in clinical dentistry.

In 2020, the Group expanded into the medical laboratories and research industry with the strategic investment into Acumen Diagnostics Pte. Ltd. (Acumen). Acumen currently focuses on the manufacture, sale and distribution of COVID-19 diagnostic test kits, as well as COVID-19 testing. It is also working to roll out a pipeline of new tests, including PCR assays for dengue, sepsis and, identification of bacterial pathogens and their associated antibiotics resistance in pneumonia and bloodstream infections.

The Group was listed on the Mainboard of the Singapore Exchange Securities Trading Limited (SGX-ST) on 26 November 2009. For more information on the Group, please visit www.QandMDental.com.sg

For more information, please contact:
Waterbrooks Consultants Pte Ltd
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Derek Yeo: derek@waterbrooks.com.sg, +65 9791-4707
General: query@waterbrooks.com.sg, +65 9690-4959

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Copyright 2023 ACN Newswire. All rights reserved. http://www.acnnewswire.com

Kingworld Medicines Earns “Shenzhen Time-honored Brand” Title Again

HONG KONG, Feb 28, 2023 – (ACN Newswire) – Headquartered in Shenzhen, Kingworld Medicines Group Limited (stock code: 01110.HK) is a distributor and the agent of many well-known and high-quality health products, providing channels and supply chains to the products. It has helped brands establish professional image and achieved good sales performance in the Mainland China, Hong Kong and Macau markets, gaining the endorsement of partners at home and abroad. As an industry leader of more than two decades, Kingworld Medicines has won market acclaims and was again named a "Shenzhen Time-honored Brand".

The Company's own medicine brand Kingworld Imada Red Flower Oil recently made the official topical oil at the Shenzhen Bao'an Marathon. The topical oil is among the best of Kingworld's own brand medicines, known for improving circulation, fending off coldness and reducing swelling and pain. Made of precious Chinese medicines, including safflower and dragon's blood, the topical oil can be used to treat symptoms of such as arthritis, and bruises and pain, backache and mosquito bites, among others.

The Shenzhen Bao'an Marathon was suspended for [a year/two years] due to the COVID-19 pandemic. It will resume this year and is scheduled to be held on 19 March. The major sports event in China was first held in December 2016. It features two races – the full marathon and half marathon – welcoming 18,000 participants, of whom 8,000 to the full marathon and 10,000 to the half marathon. In recent years, the Company has provided Kingworld Imada Red Flower Oil to athletes at various sporting events to help in their recovery. The product has also been well-received by consumers, who have spontaneously recommended it to their friends via WeChat.

Kingworld Medicines will send teams to take part in the event. On the day, a service zone will be set up at the starting point and the end point to help athletes [get ready for and] recuperate after the races. Moreover, it will offer interactive games with prizes at the event to spur the joyous atmosphere of the marathon.

The medicines, health care products and beauty products sold by Kingworld Medicines as a distributor and agent included: the Nin Jiom Product series, Taiko Seirogan, Culturelle probiotics, CARMEX, Life's DHA Algae, among others, all products familiar to the market. The Company also carries out R&D and production of medical devices such as infrared body temperature monitors, and distributes medical supplies and surgical masks. Last year, it acquired equity interest in the French company Innopharm to prepare for exploring and making deployment in overseas market.

The Company is building the Longde Health Industrial Park in Shenzhen. The industrial park was topped out at the end of last year and will start recruiting tenants this year, targeting companies in medical device and biomedicine businesses. With the Longde Health Industrial Park giving it support, Kingworld will build an integrated intelligent pharmaceutical supply chain service platform and optimize its comprehensive health business system.


Copyright 2023 ACN Newswire. All rights reserved. http://www.acnnewswire.com

Malaysian Genomics Pivots to Biopharmaceuticals for Growth

PETALING JAYA, Malaysia, Feb 24, 2023 – (ACN Newswire) – Malaysian Genomics Resource Centre Berhad, a leading genomics and biopharmaceutical specialist, today announced that the Group recorded a revenue of RM1.64 million for the second quarter ended 31 December 2022 (2Q 2023). This amount is down from RM7.63 million in 2Q 2022, as the Group moved its focus from vaccines to biopharmaceuticals.


En Azri Azerai, Executive Director of Malaysia Genomics Resource Centre Berhad


For the quarter under review, the Group recorded a loss before tax (LBT) of RM1.27 million compared with a profit before tax (PBT) of RM1.01 million in 2Q 2022, mainly due to business expansion and production of fast-moving consumer goods (FMCG), which required additional human resource capital, research and development expenditure, and marketing.

For the first six months ended 31 December 2022 (1H 2023), the Group recorded a revenue of RM5.46 million, which is a RM11.48 million decrease from the RM16.94 million registered in 1H 2022. The Group reported a LBT of RM0.43 million for 1H 2023 compared to a PBT of RM1.25 million in the corresponding period in the previous financial year.

Azri Azerai, Executive Director of Malaysian Genomics, said, "Our Group remains committed to sustaining growth over the longer term by focusing on immunotherapy and cell therapies under the biopharmaceutical business we are expanding through our distribution network in the Middle East and Southeast Asia. We are also developing new FMCG products to offer to these new markets while seeking to expand into other markets. Our recent initiatives include a commercial collaboration on an innovative genetic test for reproductive health and the development of novel phytopharmaceuticals with potential therapeutic and commercial value."

"The financial performance for the quarter under review was mainly affected by the need to spend in support of the pivot to biopharmaceuticals, which the Group is well positioned to take advantage of given our track record as a leading provider of genetic screening and genome analysis services," he added.

Malaysian Genomics Resource Centre Bhd: 0155 [BURSA: MGRC] [RIC: MGRC:KL] [BBG: MGRC:MK], http://www.mgrc.com.my/

Copyright 2023 ACN Newswire. All rights reserved. http://www.acnnewswire.com

Essex and Henlius signed amendment agreement for Global Co-Development and Exclusive License Agreement for treatment of age-related macular degeneration

HONG KONG, Feb 22, 2023 – (ACN Newswire) – Essex Bio-Technology Ltd ("Essex" or the "Group", Stock Code: 1061.HK) today announced that two of its wholly-owned subsidiaries, Essex Bio-Investment Limited ("Essex Bio-Investment") and Zhuhai Essex Bio-Pharmaceutical Co. Ltd ("Zhuhai Essex"), signed an amendment agreement (the "Amendment Agreement") with Shanghai Henlius Biotech, Inc. ("Henlius", Stock Code: 2696.HK) in relation to a global Co-Development and Exclusive license Agreement signed in October 2020 (the "Agreement"). Pursuant to the Agreement, Essex Bio-Investment and Henlius will co-develop the bevacizumab HLX04 (the "Product" or "EB12-20145P") for treatment of ophthalmic diseases such as exudative (wet) Age-related Macular Degeneration (wAMD). Essex Bio-Investment has an exclusive global license to develop, manufacture, and commercialise the Product in the field of human ophthalmic therapeutic use and/or therapies.

Reasons for, and benefits of, the entering into the Amendment Agreement

As a result of the (i) increased cost of clinical trial operations; (ii) increased cost of patient recruitment for the clinical trial programme; (iii) general inflation in the global economy and manpower shortage in the healthcare sector during and following the COVID-19 pandemic; and (iv) increased cost associated with the establishment of new clinical trial sites in the United States and Europe to support and balance requirements imposed by various regulatory authorities for the clinical trials, the development costs of the Product have materially increased since the signing of the Agreement. Therefore, to tackle the increasing development costs and to support the continuous research and development of the Product further, Essex Bio-Investment has agreed to provide additional funding towards Henlius by entering into the Amendment Agreement.
Amended terms

(i) Payments for regulatory and commercial sales milestones

(a) The regulatory milestone payment from Essex Bio-Investment to Henlius payable upon the completion of the clinical trial programme has been adjusted from US$10,000,000 (equivalent to approximately HK$78,400,000) or its Renminbi equivalent to US$8,000,000 (equivalent to approximately HK$62,720,000) or its Renminbi equivalent.

(b) The amount to be paid by the Licensee to the Licensor after the commercialisation of the Licensed Products, in the event where the Licensee commercialises the Licensed Product by itself only, shall be adjusted as follows:

Commercial sales milestone payments (which shall be paid once only) of US$1,500,000 (adjusted downwards from US$3,000,000 in the Agreement, equivalent to approximately HK$11,760,000), and US$7,500,000 (adjusted downwards from US$15,000,000 in the Agreement, equivalent to approximately HK$58,800,000).

(ii) Development costs

The arrangement of development costs will be amended as follows:

Subject to the terms of the Agreement and the Amendment Agreement, the Licensee has agreed to share the development costs with the Licensor in the aggregate amount up to US$55,000,000 (adjusted upwards from US$30,000,000, equivalent to approximately HK$431,200,000) as to 80% by the Licensee (i.e., up to US$44,000,000 (equivalent to approximately HK$344,960,000) ("Amended Essex Funding")) and as to 20% by the Licensor. The Amended Essex Funding shall be payable in accordance with the funding schedule agreed with reference to the achievement of the specified milestones.

All other principal terms of the Agreement remain unchanged.

Current status

Currently, the EB12-20145P (HLX04-O) project has completed first patient dosing in the EU, Australia, and the US, and has been licensed for clinical trials in Singapore and other countries and regions. Essex and Henlius will progressively jointly manage the global multi-centred clinical trials of EB12-20145P (HLX04-O) and apply marketing authorisation in China, Australia, the EU, the US, and ASEAN around the globe based on the research results. EB12-20145P (HLX04-O) has the potential to be one of the first bevacizumab products approved for use in ophthalmic diseases, benefiting more patients with eye diseases worldwide.

Essex's Board believes that Essex Bio-Investment entering the Amendment Agreement with Henlius will provide assurance that the clinical trial programme under the Agreement will remain undisrupted under Essex and Essex Bio-Investment's control with the intent of moving towards progressive completion of the clinical trial programme within the scope of the clinical trial programme.

About Essex (1061.HK)

Essex Bio-Technology Limited is a bio-pharmaceutical company that develops, manufactures and commercialises genetically engineered therapeutic b-bFGF (FGF-2), having six commercialised biologics marketed in China since 1998. Additionally, it has a portfolio of commercialised products of preservative-free unit-dose eye drops and Shilishun(Iodized Lecithin Capsules) etc.. The products of the Company are principally prescribed for the treatment of wounds healing and diseases in Ophthalmology and Dermatology, which are marketed and sold through approximately 10,710 hospitals and managed directly by its 43 regional sales offices in China. Leveraging on its in-house R&D platform in growth factor and antibody, the Company maintains a pipeline of projects in various clinical stages, covering a wide range of fields and indications.

Media Enquiry:
Strategic Financial Relations Limited (Website: http://www.sprg.com.hk)
Shelly Cheng +852 2864 4857 shelly.cheng@sprg.com.hk
Yan Li +852 2114 4320 yan.li@sprg.com.hk
June Tuo +852 2864 4848 june.tuo@sprg.com.hk
Angela Shen +852 2864 4870 angela.shen@sprg.com.hk
Media: media@essex.com.cn

Investor Enquiry:
Investor Relations: investors@essex.com.cn


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